硫酸锌对肠缺血-再灌注损伤的防治作用  

Preventive and therapeutic effect of zinc sulfate on intestinal ischemia-reperfusion (I/R) injury

作　　者：赵春秀[1] 景有伶[1] 段国贤[1] 李宏杰[1] 张连元[1] 张硕森[1] 

机构地区：[1]华北煤炭医学院基础医学部生理学教研室,河北唐山063000

出　　处：《华北煤炭医学院学报》2003年第2期133-134,共2页Journal of North China Coal Medical College

基　　金：河北省煤炭厅基金(编号:961416004517)

摘　　要：①目的 探讨硫酸锌对肠缺血-再灌注(ischemia-reperfusion,I/R)损伤的防治作用及其机制。②方法 复制家兔肠I/R损伤模型,观察硫酸锌对超氧化物歧化酶(SOD)、黄嘌呤氧化酶(XO)及丙二醛(MDA)含量的影响、实验分为I/R损伤组、硫酸锌+I/R组和假手术组(Sham)对照组,并进行比较。③结果 缺血前3组动物红细胞S0D、红细胞膜及血浆MDA、血浆XO值均无统计学差异,I/R组再灌注后2h与缺血前及Sham组相比,SOD活性显著下降,XO活性及MDA含量明显增加(P<0.01);此外,肠、肺、肝等组织MDA含量亦明显高于Sham组(P<0.01)。静脉给予硫酸锌,可使XO及MDA含量降低,且可防止SOD减少。④结论 肠I/R过程中伴有多器官脂质过氧化损伤,硫酸锌通过抗脂质过氧化能减轻或在一定程度上避免再灌注损伤的进一步加剧。Objective To investigate the preventive and therapeutic effects of zinc sulfate on intestinal ischemia-reperfusion (I/R) injury and their mechanism of action. Methods Models of rabbits intestinal I/R injury was made. The effect of zinc sulfate on superoxid dismutase(SOD) ,oxidase(XO) and malondialdevde (MDA) were observed. Re-sults The administration of zinc sulfate could decrease XO and MDA, prevent the reduction of SOD, and alleviated I/R injury. Conclusions It is suggested that lipid peroxidation injurv is one of the pathogenesis of I/R injury, and zinc sulfate possesses preventive and therapeutic effect, through anti-lipid peroxidation.

关 键 词：缺血-再灌注损伤 脂质过氧化 硫酸锌 多器官损伤 

分 类 号：R331.32[医药卫生—人体生理学]