空服与饱服大剂量烟酸缓释片的药动学  

Study on pharmacokinetics of nicotinic acid sustained release tablet in empty stomach and foods after a high oral dose

作　　者：邓立东[1] 蒋学华[2] 陈钧[2] 卢来春[2] 周静[2] 

机构地区：[1]桂林医学院附属医院,广西桂林541001 [2]四川大学华西药学院,四川成都610041

出　　处：《中国医院药学杂志》2003年第3期129-131,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :研究健康志愿者口服烟酸缓释片 (1 50 0mg)的药动学。 方法 :1 8名健康志愿者随机分成两组 ,一组禁食 1 2h后 ,空服烟酸缓释片 1 50 0mg。另一组进食统一餐后 ,口服烟酸缓释片 1 50 0mg。比较两组的药动学参数。 结果 :烟酸缓释片的体内过程符合具有一级吸收的一室模型 ,其主要的药动学参数Tmax,Cmax和AUC0→∞ 分别为 (3 .2± 0 .3)h和 (3 .2± 0 .3)h ;(5 .3± 1 .4)mg·L- 1 和 (5 .5± 1 .0 )mg·L- 1 ;(43 .4± 1 3 .9)mg·h·L- 1 和 (46 .2± 1 0 .2 )mg·h·L- 1 。结论OBJECTIVE To study the pharmacokinetics of nicotinic acid sustained release tablet in healthy volunteers after a high oral dose of 1500 mg.METHODS 18 healthy volunteers were divided into two groups at random.After fasting for 12 hours,one group took orally 1500 mg nicotinic acid sustained release tablet on a empty stomach. The other group took orally 1500 mg nicotinic acid sustained release tablet after breakfast.The pharmacokinetic parameters of the two groups were compared.RESULTS The pharmacokinetics of nicotinic acid sustained release tablet was fitted to a one compartment model with first order absorption. The T max , C max ,AUC 0→∞ were ( 3.2 ± 0.3 ) h and ( 3.2 ± 0.3 ) h, ( 5.3 ± 1.4 ) mg·L -1 and ( 5.5 ± 1.0 ) mg·L -1 , ( 43.4 ± 13.9 ) mg·h·L -1 and ( 46.2 ± 10.2 ) mg·h·L -1 . CONCLUSIONS The study presented useful information for clinical trials.

关 键 词：烟酸缓释片 血药浓度 药动学 

分 类 号：R969[医药卫生—药理学]