长沙地区淋球菌流行株的药物敏感性检测  

Antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha

作　　者：邹明祥[1] 夏忠弟[2] 梁湘辉[1] 陈淑贞[2] 唐银[1] 刘海连[1] 

机构地区：[1]中南大学湘雅医院检验科,长沙410008 [2]中南大学湘雅医学院微生物教研室,长沙410078

出　　处：《湖南医科大学学报》2003年第1期53-55,共3页Bulletin of Hunan Medical University

摘　　要：目的 :了解长沙地区淋球菌流行株对抗菌药物的敏感性 ,为淋病的防治提供实验依据。方法 :改良碘量法检测 β 内酰胺酶 ,纸片扩散法检测 86株淋球菌对 9种抗菌药物的敏感性。结果 :质粒介导的产青霉素酶淋球菌(PPNG)和质粒介导的高度耐四环素淋球菌 (TRNG)分别为 35株 (40 .6 9% )和 2 0株 (2 3.2 6 % )。在测定的 9种抗菌药物中 ,淋球菌耐药性较高的依次为四环素、头孢美唑、青霉素、环丙沙星、氧氟沙星 ,耐药率分别为 4 5 .35 % ,5 0 .0 0 % ,6 2 .79% ,77.91% ,87.2 1%。而敏感性较高的 4种抗菌药物依次为头孢呋辛、头孢三嗪、头孢吡肟、壮观霉素 ,敏感率分别为 77.91% ,80 .2 3% ,86 .0 5 % ,98.84 %。结论 :青霉素、四环素以及氟喹诺酮类药物已不宜作为长沙地区治疗淋病的常规药物 ;壮观霉素可作为治疗淋病的首选药物 ,但已出现耐药菌株 。Objective To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha and to provide a reference for the prevention and treatment of gonorrhea. Methods β Lactamase was determined by a modified iodometric method and the susceptibility to 9 antibiotic agents was tested by the disc diffusion method in 86 isolates. Results Plasmid mediated penicillinase producing Neisseria gonorrhoeae and plasmid mediated tetracycline resistant Neisseria gonorrhoeae were 40.69% and 23.26%, respectively. Of all the 9 antibiotic agents, tetracycline, cefmetazole, penicillin, ciprofloxacin, and ofloxacin had a higher resistance and the percentages of resistance were 45.35%, 50.00%, 62.79%, 77.91%, and 87.21%, respectively. On the other hand, cefuroxime, ceftriaxone, cefepime, and spectinomycin had a higher susceptibility and the percentages of susceptibility were 77.91%, 80.23%, 86.05%, and 98.84%, respectively. Conclusion Penicillin, tetracycline and fluoroquinolone can not be used as routine agents to cure gonorrhea; and spectinomycin can be used as primary medicine to cure gonorrhea in Changsha,but clinical doctors need to pay more attention to it because resistant strains have come into existance.

关 键 词：淋球菌 纸片扩散法 药物敏感性 长沙 

分 类 号：R446.5[医药卫生—诊断学]