不稳定性心绞痛患者与健康人群血小板活性因子对比研究  

Study on platelet active factors in Patients with unstable angina and healthy People

作　　者：刘成华[1] 肖兴花[1] 付存玉[1] 

机构地区：[1]山东省临沂市沂水中心医院,山东临沂276400

出　　处：《河北医学》2003年第1期61-62,共2页Hebei Medicine

摘　　要：目的 :观察血小板功能及某些活性因子的含量变化 ,了解其在不稳定型心绞痛发病过程中的作用。方法 :选择不稳定性心绞痛患者及健康查体者为研究对象 ,采集清晨动脉血测定体外血小板最大聚集率及血小板活性因子含量。结果 :不稳定性心绞痛患者TXB2 ,GMP - 40含量分别为 112 .4 3± 30 .2 8ng/L ,2 1.14± 4 .87μg/L ;健康者分别为 86 .82± 13.6 8ng/L ,10 .12± 4 .92 μg/L ;血小板最大聚集率 ,不稳定性心绞痛患者为 84 .87% ,健康者为 6 3.6 0 % ,各项参数两组比较P均 <0 .0 1,差异有非常显著性意义。结论 :血小板功能状态及某些活性因子的释放 ,在不稳定性心绞痛发病过程中具有十分重要的作用。Objective: To investigate the levels of platelets active factors and the effects of platelets in patients with unstable angina . Methods: the PAGF-Max and the plasma levels of TXB 2 and GMP-40 in arterial blood in 56 cases patients with unstable angina were detected, while 67 cases healthy people served as controls. Results: There were higher levels of TXB 2 and GMP-40 in patients with unstable angina than those of the controls (112.43±30.28ng/l vs. 86.82±13.68ng/l, P<0.01; 21.14±4.87ug/l vs. 10.12±4.92ug/l, P>0.01), and showed higher PAGF-Max in unstable angina patients 84.87% vs.63.60%. Conclusion: the functions and the release of active factors of platelets have effects on the mechanical processes of unstable angina.

关 键 词：不稳定性心绞痛 患者 健康人群 血小板活性因子 

分 类 号：R541.4[医药卫生—心血管疾病]