电刺激束旁核、中央外侧核对猫丘脑后核群内脏痛放电影响的对比研究  

Effects of Electrically Stimulating Parafascicular Nucleus and Central Lateral Nucleus on Visceral Pain Discharges in Posterior Group of Thalamic Nuclei of Cats

作　　者：江敏[1] 吴敏范[2] 朱启文[2] 

机构地区：[1]沈阳医学院医学基础部病理生理学教研室,辽宁沈阳110034 [2]沈阳医学院医学基础部生理学教研室,辽宁沈阳110034

出　　处：《沈阳医学院学报》2003年第1期9-10,共2页Journal of Shenyang Medical College

摘　　要：目的 :研究束旁核、中央外侧核在痛觉调制中的作用及机理。方法 :以电刺激内脏大神经在丘脑后核群诱发的单位放电作为内脏痛指标 ,应用细胞外玻璃微电极记录技术及条件 检验刺激技术 ,研究电刺激束旁核、中央外侧核对内脏痛放电的影响。结果 :束旁核、中央外侧核对丘脑后核群内脏痛放电主要表现为抑制作用 ,抑制作用形式分为即时抑制、延迟抑制及持续抑制。结论 :束旁核、中央外侧核参与内脏痛的调制 ,主要为抑制内脏痛 ;Objective: To study the effect of parafascicular nucleus (PF) and central lateral nucleus (CL) on pain and their mechanisms. Methods:As an index of visceral pain, the discharges of the neurons in the posterior group of thalamic nuclei (PO), evoked by stimulating greater splanchnic nerve (GSN) in 50 cats were investigated extracellularly.The effects of PF and CL on the unit discharges were also studied with test-conditioning stimulation techniques. Results:We stimulated PF or CL (conditioning stimulus) electrically. The neuron discharges in PO, caused by excitation of GSN (test stimulus), were mainly depressed. The inhibitory forms of PF or CL could be classified into 3 kinds: prompt, delayed, and continued inhibition. Conclusion:The PF and CL were involved in the regulation of visceral pain, mainly in analgesia of visceral pain. The inhibitory effect of PF were stronger than that of CL.

关 键 词：内脏痛 束旁核 中央外侧核 丘脑后核群 内脏大神经 

分 类 号：Q438[生物学—生理学]