缬沙坦对心力衰竭患者心功能及QT离散度的影响  

Effect of Valsartan on Heart Function and QT Dispersion in Patients with Heart Failure

作　　者：刘向儒[1] 谭小军[1] 张晓红[1] 陈小亮[1] 王仲华[1] 

机构地区：[1]湖南省郴州市第一人民医院心内科,423000

出　　处：《医药导报》2003年第3期156-158,共3页Herald of Medicine

摘　　要：目的 :观察缬沙坦对扩张型心肌病 (DCM)心力衰竭 (心衰 )患者心功能及QT离散度 (QTd)的影响。方法 :DCM心衰患者 84例 ,分为两组。治疗组 44例 ,用缬沙坦 80mg,qd,对照组 40例 ,接受常规 (包括卡托普利 2 5mg ,bid)治疗 ,疗程均为 1个月。两组治疗前后观察临床疗效 ,检查心脏彩色B超 ,同时检查心电图测量QTd。比较两组以上三方面变化。结果 :治疗组在临床疗效、心功能变化及QTd变化方面明显优于对照组。结论 :缬沙坦治疗DCM明显优于卡托普利 ,对于DCM心衰的患者 ,应早期尽快使用缬沙坦 ,这对于阻止心肌的进一步损伤 ,保护心脏功能 。Objective:To evaluate the effect of valsartan on QT dispersion and heart function in patients with dilated cardiomyopathy(DCM). Methods:Among the 84 DCM patients, 44 underwent valsartan treatment and 40 underwent captopril treatment. The QTd and heart function were observed and compared after 2 weeks. Results:The treatment group was superior to the control group in therapeutic effect, changes of heart function and changes of QTd. Conclusion:valsartan in treating DCM is batter than captopril in improving function of the left ventricle and reducing the occurrence of arrhythmias.

关 键 词：缬沙坦 心肌病 扩张型 QT离散度 心力衰竭 

分 类 号：R972.3[医药卫生—药品] R542.2[医药卫生—药学]