盐酸洛美沙星滴眼液的制备  

Preparation of Lomefloxacin Hydrochloride Eye-drops

作　　者：王剑林 

机构地区：[1]陕西省富平县人民医院药剂科,711700

出　　处：《医药导报》2003年第3期182-183,共2页Herald of Medicine

摘　　要：目的 :以玻璃酸钠为载体制备盐酸洛美沙星滴眼液 ,增加滴眼液粘稠度和润滑性 ,以增强疗效 ,减少给药次数。方法 :经筛选选定处方及制备方法 ,对其质量控制、稳定性、刺激性进行考察 ,并对临床效果作了初步观察。结果 :玻璃酸钠的加入不影响主药性质 ,对含量检测方法无干扰 ,经留样观察 1 8个月表明质量稳定 ,临床应用生物相容性好 ,有效率 96.5 %。结论 :该制剂处方合理 ,工艺简便 ,质量稳定 。Objective:Using the sodium hyaluronate as carrires, to improve the concentration and lubricity of the eye drops, increase the effects and decrease the dosage. Methods:The preparation of the eye drops and its qualities including characters, concentration and stability were studies. Its clinical effects were also observed. Results:Sodium hyaluronate did not change the characters of LFLX or interfere with the concentration. Having been observed for 18 months, it showed a better quality and biointermiscibility, the effective rate of the eye drops being 96.5%. Conclusion:The method is simple with good stability, and the rapeutic effects.

关 键 词：洛美沙星 盐酸 玻璃酸钠 制备 

分 类 号：R978.1[医药卫生—药品]