新型生物可降解交联N—乙烯基吡咯烷酮(NVP)材料的制备  

Preparation of Novel Biodegradable Crosslinked N-vinylpyrrolidone(NVP) Scaffold Materials

作　　者：焦延鹏[1] 张志雄[1] 李立华[1] 周长忍[1] 

机构地区：[1]暨南大学化学系生物材料研究室,广州510632

出　　处：《山东生物医学工程》2002年第3期9-11,共3页Shandong Journal of Biomedical Engineering

基　　金：国家科技部重大基础研究项目 ("973"项目G19990 5 43 0 6)

摘　　要：用甘油和丙交酯在辛酸亚锡的催化下合成了可降解的三羟基中间体 ,在三乙胺存在的条件下 ,末端用丙烯酰氯进行功能化 ,合成了可降解的三乙烯基交联剂 ,并且对中间体和交联剂进行了FTIR ,1H—NMR ,GPC分析表征。这种交联剂与乙烯基吡咯烷酮 (NVP)用偶氮二异丁氰 (AIBN)为引发剂自由基引发聚合制备了组织工程支架材料 ,并且对材料的基本性能(吸水率和接触角 )进行了分析表征。The biodegradable crosslinking agent was synthesized by polycondensation reaction of lactide using glycerol as initiator and stannous octoate as catalyst,followed by functionalization of the hydroxyl end group with acryloyl chloride in the presence of triethyl amine.The polymer were characterized using GPC,FTIR and 1 H -NMR ananlysis. The novel biodegradable crosslinked NVP scaffold material was prepared by radical polymerization of the biodegradable crosslinking agent and NVP using azoisobutyronitrile(AIBN)as initiator.The characterization of material,ratio of water absorption and contact angle,was also elucidated.

关 键 词：可降解 交联剂 N-乙烯基吡咯烷酮 

分 类 号：R318.08[医药卫生—生物医学工程]