谷胱甘肽硫转移酶基因多态性与慢性阻塞性肺病易患性的研究  

Genetic polymorphisms of GSTM1 gene related to chronic obstructive pulmonary disease

作　　者：王溯[1] 王云杰[1] 金维澍[2] 刘锟[1] 谭刚[3] 

机构地区：[1]第四军医大学唐都医院胸外科,西安710038 [2]哈尔滨医科大学第二附属医院胸外科,黑龙江150086 [3]哈尔滨医科大学第一附属医院普外科,黑龙江150001

出　　处：《军医进修学院学报》2003年第1期69-71,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的 :探讨谷胱甘肽硫转移酶基因 (GSTM1)多态性与慢性阻塞性肺病易患性的关系。方法 :用病例对照研究方法和Multiplex PCR技术检测慢性阻塞性肺病患者 78例和住院对照 71例 ,分析GSTM1基因缺失型 (GSTM1(- ) )频率分布 ,探讨GSTM1基因缺失型及吸烟量与慢性阻塞性肺病的易患性。结果 :GSTM1基因缺失型在病例和对照组的频率分别为 5 8 97%、5 3 5 2 % (P >0 0 5 ) ,无显著性差异。GSTM1基因缺失型与吸烟量 (>2 0包 年 )联合作用 ,慢性阻塞性肺病易患性增加 5 36倍 (95 %可信区间 2 15～ 13 2 1)。结论Objective:The genetic polymorphisms of glutathione S transferase (GSTM1) gene were analyzed probed for the genetic marker of chronic obstructive pulmonary disease Methods: The case control study was conducted among 78 chronic obstructive pulmonary disease cases and 71 hospitalized controls The genetic polymorphisms were tested with method of Multiplex PCR We investigated susceptibility to chronic obstructive pulmonary disease in relation to GSTM1 (-) genotype combination with cigarette smoking dose Results: The frequencies of GSTM1 (-) were 58 97% and 53 52% respectively in chronic obstructive pulmonary disease group and control group ( P >0 05) Individuals with GSTM1 (-) genotype combination with cigarette smoking dose ( >20 pack years) were at remarkably high risk susceptibility to chronic obstructive pulmonary disease with an odds ratio of 5 36 (95%CI 2 15～13 21) Conclusion: Genetic polymorphisms in GSTM1 combination with cigarette smoking dose were associated with the development of chronic obstructive pulmonary disease in China

关 键 词：谷胱甘肽转移酶 基因 多态现象遗传学 肺疾病 阻塞性 吸烟 

分 类 号：R563[医药卫生—呼吸系统]