东莨菪碱对心肺复苏后急性脑缺血-再灌流损伤的保护作用  

The protective effects of scopolamine on acute cerebral ischemia reperfusion injury.

作　　者：李士玉[1] 马玉玲[1] 李治红[1] 冯国伟[1] 郭向杰[1] 杨海卫[1] 

机构地区：[1]山东省济宁医学院附属医院急诊科,272013

出　　处：《中华急诊医学杂志》2003年第1期38-39,共2页Chinese Journal of Emergency Medicine

摘　　要：目的　探讨东莨菪碱对急性脑缺血再灌注损伤的保护作用。方法　 32例患者按顺序随机分为治疗组 (A组 )与对照组 (B组 )。A组 18例给予东莨菪碱 0 6～ 0 9mg +5 %GS2 5 0～ 5 0 0ml持续静滴 ,每日 <3mg ,疗程 5～ 7天。B组除不用东莨菪碱外 ,其他治疗同A组。结果　A组治疗后显效 12例 ,有效 4例 ,无效 2例 ,总有效率 88 9% ;B组有效率为 71 5 % ,两组比较有显著性差异 ,P <0 0 5。Objective To evaluate the protective effect of scopolamine against acute cerebral ischemia reperfusion injury.Methods thirty-two patients were divided randomly ino the treatment group(group A) and the control group(group B).Eighteen patients in group A were given scopolamine 0 6～0 9mg+5%GS 250～500ml continuous refusion for five or seven days.Daily dosage was less than 3 mg.B group patients were treated as A group patients except without scopolamine.Results The effect of A group after treatment was significunt in twelve patients.Four patients was effective.It was ineffective in two patients.The total effective value was 88 9%.The total effective value in group B was 71 5%.There was signficantly differences between group A and group B. P <0 05.Conclusion The study showed that with scopolamine had definite protective effect in the recovery of brain function in the patients with acute cerebral ischemia reperfusion injury.[

关 键 词：东莨宕碱 脑缺血 再灌注损伤 

分 类 号：R459.7[医药卫生—急诊医学]