甲氧氯普胺口溶片的处方筛选及体外溶出度特性  

Studies on Preparation and Dissolution in Vitro of Rapid Dissolving Tablet in Mouth of Metoclopramide

作　　者：杨延莉[1] 吴学孔[2] 肖正达 李晏 曹尉尉 黄小琴 

机构地区：[1]中国人民解放军海军第411医院,上海200081 [2]中国人民解放军海军卫生部,北京100841

出　　处：《解放军药学学报》2003年第1期32-34,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　研制甲氧氯普胺口溶片 ,并比较其与普通市售片的体外溶出度。方法　正交设计法优化甲氧氯普胺口溶片的处方 ,制备最佳工艺 ,进行溶出度比较研究。结果　正交试验优选的最佳工艺为A2 B1C3 D1。优选后制备的口溶片较普通片的溶出特征有显著差异 ,口溶片的释放速率明显快于普通片。Aim To study the preparation and dissolution in vitro of rapid dissolving tablets of Metoclopramide in mouth.Methods Orthogonal design was used to optimize the composition of the rapid dissolving tablets of Metoclopramide in mouth.The dissolution method was used to establish methodology capable of showing the subsequent in vitro performance of rapid dissolving tablets of Metoclopramide and market tablet.Results The optimum procedure was A 1B 3C 1D 3.The dissolution of rapid dissolving tablets distinguished market tablets remarkably,the release rate of the former was faster than that of the latter.Conclusion The dissolution of rapid dissolving tablets was higher than that of market tablets.

关 键 词：甲氧氯普胺 口溶片 正交设计 溶出度 

分 类 号：R944.4[医药卫生—药剂学]