盐酸吡哆辛及其制剂的二阶导数差示脉冲极谱法定量研究  

STUDY ON QUANTITATIVE ANALYSIS OF PYRIDOXINE HYDROCHLORIDE AND ITS PREPARATION BY SECONDARY DERIVATIVE DIFFERENTIAL PULSE POLAROGRAPHY

作　　者：王连朋 申永壮 梁云爱 

机构地区：[1]日照市药品检验所,日照276800

出　　处：《化学分析计量》2003年第2期24-26,共3页Chemical Analysis And Meterage

摘　　要：建立盐酸吡哆辛及其制剂的二阶导数差示脉冲极谱定量分析方法。盐酸吡哆辛在0.1mol/L氢氧化钠溶液-0.1moL/L磷酸二氢钾溶液-水(体积比为1.2:8.8:990)的混合溶液中,于-0.140V(vs·Ag/AgCl)处出现一良好的二阶导数差示脉冲极谱峰,盐酸吡哆辛浓度在3.6×10^(-4)～9.6×10^(-4)mol/L范围内与其峰幅值呈显著的线性关系(P<0.01),线性相关系数r=0.9997,检出限为9.0nmol/L。A method for the quantitative analysis of the pyridoxine hydrochloride and its preparation were estahlished. There is a very good secondary derivative differential pulse polarogram peak at-0. 140 V ( vs·Ag/AgCl) in 0. 1 mol/L sodium hydroxide -0. 1 mol/L potassium dihyrogen phosphate-water (the volume ratio is 1.2 : 8. 8 : 990) solution. The linear relationship between the concentration of pyridoxine hydrochloride and the peak height is good in the range of 3.6×10-4~9. 6×10-4 mol/L ( P < 0. 01 ). The linear correlation coefficient is 0.9997. The detection limit is 9.0 nmol/L. The method is simple, accurate, rapid and sensitive.

关 键 词：盐酸吡哆辛 二阶导数差示脉冲极谱法 定量分析 抗肿瘤药物 

分 类 号：R979.1[医药卫生—药品] R917[医药卫生—药学]