天智颗粒治疗老年血管性痴呆临床观察  

Clinical Study of Effect of Tianzhi Granule on Senile Vascular Demetia

作　　者：杜贵友[1] 朱新成 赵建军[3] 王健[3] 田金州[4] 刘显峰 支惠萍[5] 赵雍[1] 曹春雨[1] 崔海峰[1] 王秀荣[1] 张春颍 

机构地区：[1]中国中医研究院中药研究所,北京100700 [2]河南省宛西制药厂,河南宛西474550 [3]长春中医学院附属医院,吉林长春130005 [4]北京中医药大学东直门医院,北京100700 [5]上海中医药大学曙光医院,上海200021

出　　处：《中国中药杂志》2003年第1期73-77,共5页China Journal of Chinese Materia Medica

基　　金：国家科委新药基金资助课题 ( 96 90 10 5 71);国家自然科学资金资助课题 ( 30 17185 );北京市自然科学资金资助课题( 70 12 33)

摘　　要：目的 :观察天智颗粒 (TZK)治疗老年血管性痴呆 (vasculardementia ,VaD) ;以肝阳上亢型为主症的临床疗效。方法 :将 2 0 0例VaD患者采用TZK治疗 ,每次 1包 (5 .0 g/包 ) ,每日 3次口服 ,1个月为一个疗程 ,连续 2个疗程。结果 :给药后可以显著改善认知功能和行为能力 ,与阳性药都可喜比较未见显著性差异 (P >0 .0 5 ) ,同时可显著改善中医临床证候及生活能力 ,对异常血粘度患者可以降低其不同切变率下全血粘度、降低血浆粘度 ,对红细胞变形和聚集指数异常均有显著改善作用。结论 :TZK对肝阳上亢型老年血管性痴呆有一定的疗效。Objective:To investigate the clinical effect of Tianzhi Granule (TZK) on senile vascular dementia (VaD), which is classified as sthenia of liver-yang'. Method:Two hundred VaD patients were treated with TZK (0.5 g/bag),which was taken one bag each, three times a day. The treatment course was one month and they were treated for rwo courses. Result:TZK could remarkably increase gnosia and activity,with no striking difference from that of positive control group ( P >0.05). Simultaneously, TZK could significantly improve the clinical syndrome of traditional Chinese medicine and viability. It could also drastically reduce the whole blood and plasma viscosity and improve erythrodegeneration and abnormality of aggregation index in the abnormal blood viscosity patients.Conclusion:TMC has certain effects on senile VaD.

关 键 词：天智颗粒 老年性血管性痴呆 TZK 疗效 治疗 

分 类 号：R277.7[医药卫生—中医学]