防疤烧伤膏对大鼠伤口愈合的影响  

Effect of Fangba Shaoshang ointment(防疤烧伤膏) on wound healing in rats

作　　者：董永洪[1] 包海芬 焦福成[1] 朱卫东[1] 程群[1] 

机构地区：[1]武警浙江省消防总队医院,浙江杭州310011

出　　处：《中国中西医结合急救杂志》2003年第2期96-98,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的 :观察防疤烧伤膏对大鼠创面修复的影响。方法 :采用大鼠皮肤切割伤模型 ,创面外用防疤烧伤膏 ,并采用碱性成纤维细胞生长因子 ( basic fibroblast growth factor,b FGF)和空白处理作为阳性和阴性对照。透明膜标记称量法和注水法记录伤后 3d、7d和 14d创面面积和伤腔容积 ,伤后 7d和 14d取创面组织进行组织学检查。结果 :防疤烧伤膏能够减轻伤口炎症反应 ,促进坏死组织脱落 ,缩短伤口愈合时间。结论 :外用防疤烧伤膏对创面修复有促进作用。Objective:To explore the effect of Fangba Shaoshang ointment(防疤烧伤膏) on wound healing in rats.Methods:Cuttingskin injures model in rats were created.Wounds were treated with Fangba Shaoshang ointment.At the same time,therapies with basic fibroblast growth factor(bFGF) and placebo were thought as positive and negative controls respectively.Wound area and volume were examined at 3,7 and 14 days after injury with the hyaline membrance tracing and measuring method and infusing water method.Tissue morphology was examined at 7 and 14 days after injury.Results:Treatment with Fangba Shaoshang ointment could alleviate inflammatory response,induce shedding of necrotic tissues,and accelerate the process of reepithelialization.Conclusion:Fangba Shaoshang ointment can stimulate wound healing.

关 键 词：创伤 碱性成纤维细胞生长因子 伤口愈合 防疤烧伤膏 

分 类 号：R285.5[医药卫生—中药学]