活血化瘀类方对动脉粥样硬化家兔血脂、血液流变学变化的影响  

An Experimental Study on the Therapeutic Effects of Formulae with the Effects of Quickening the Blood and Transforming Stasis on Serum Lipid Level and Hemorheology among Rabbits with Atheriosclerosis

作　　者：罗尧岳[1] 周小青[1] 谢小兵[1] 王大安[1] 危玲[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《湖南中医学院学报》2003年第1期9-12,共4页Journal of Hunan College of Traditional Chinese Medicine

基　　金：教育部青年骨干教师科研基金资助项目(200065)

摘　　要：目的探讨活血化瘀类方对动脉粥样硬化 (AS)家兔血脂、血液流变学的影响 ,比较其作用的异同。方法采用高脂喂饲复制家兔动脉粥样硬化模型 ,观察各组家兔血脂、血液流变学改变。结果血府逐瘀汤能显著降低家兔血清TC、TG、LDL C含量 ,亦能降低家兔全血粘度 (低切、高切 )、血浆粘度、红细胞比容 (P<0 .0 1 ) ;活络效灵丹能明显降低血清TC、LDL C含量 (P <0 .0 1 ) ,亦能降低家兔全血粘度 (低切 ) (P <0 .0 1 )、红细胞比容 (P <0 .0 5 ) ;失笑散能降低家兔血清TC、TG、LDL C含量以及红细胞比容 (P <0 .0 5 ) ;桃红四物汤明显降低血清TG含量以及全血粘度 (低切 ) (P <0 .0 1 ) ,亦能降低家兔全血粘度 (高切 ) (P <0 .0 5 ) ;丹参饮能明显降低全血粘度 (低切、高切 )、红细胞比容 (P <0 .0 1 ) ,亦能降低血清TC、LDL C含量 (P <0 .0 5 )。结论 5首活血化瘀方均有不同程度地调节血脂代谢、改善血液流变学、抑制高脂喂饲家兔动脉粥样硬化形成的作用 ,其中以血府逐瘀汤。?Objective To compare the therapeutic effects of these formulae with the effects of quickening the blood and transforming stasis on serum lipid level and hemorheology among rabbits with experimental atheriosclerosis.Methods Atheriosclerosis model was prepared among rabbits by feeding high cholesterol diet at first. Then, concentrated decoctions of the formulae to be studied here were gastrically fed to animals, one group with one formula, and serum lipid level and hemorheology were determined respectively among all the animals before and after treatment.Results All the formulae studied here held effects on serum lipid level and hemorhedogy at various degrees to these experimental animals. Among them, Xuefuzhuyu Decoction mainly decreased the levels of TG, TC, LDL C,whole blood viscosity, plasma viscosity and hematocrit, Huoluoxiaolin Elixir significantly influenced the levels of TC, LDL C,whole blood viscosity and hematocrit, Shixiao Powder Obviously declined the levels of TC, TG, LDL C and hematocrit, Taohongsiwu Decoction remarkably brought down the levels of TG and whole blood viscosity, and Danshen Beverage largely induced the levels of whole blood viscosity, hematocrit, TC and LDL C decreasing, all being in the range of significant values?(P<0.05～0.01).Conclusions Xuefuzhuyu Decoction and Huoluoxiaolin Elixir hold the strongest effects on the serum lipid level and hemorheology of rabbits with experimental atheriosclerosis among the studied formulae here, while the others have various degrees of effects on these indexes. 〔

关 键 词：活血化瘀 动脉硬化 血脂 血液流变学 实验研究 

分 类 号：R285.5[医药卫生—中药学]