黄芪丹参滴丸抗垂体后叶素致大鼠急性心肌缺血的实验研究  

Experimental Study on Effect of Huangqi Danshen Drop Pill on Pituitary - Induced Acute Myocardium Ischemia

作　　者：王怡[1] 高秀梅[1] 张伯礼[1] 

机构地区：[1]天津中医学院中药研究中心,天津300193

出　　处：《中药新药与临床药理》2003年第2期91-93,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家重点基础研究发展规划项目(973)-方剂关键科学问题基础研究(编号G1999054403)

摘　　要：目的观察黄芪丹参滴丸抗垂体后叶素(Pit)致大鼠急性心肌缺血的作用。方法采用大鼠舌下静脉注射Pit造成急性心肌缺血模型,观察各给药组在注射Pit后不同时间点Ⅱ导联心电图T波变化百分率以及对血清LDH、cK、SOD、MDA含量的影响。结果 黄芪丹参滴丸能明显对抗Pit引起的急性心肌缺血的心电图T波抬高,提高血清SOD活性,降低MDA含量。结论 黄芪丹参滴丸具有显著对抗Pit致大鼠急性心肌缺血的作用。Objective To observe the effect of Huangqi Danshen Drop Pill(HDDP) on pituitary (Pit) induced acute myocardium ischemia. Methods Acute myocardium ischemia rat model was established by sublingual venous injection of Pit(0. 35U/kg). The changes of the T wave ( II channel ECG) and serum contents of lactate dehydrogenase (LDH), CK, superoxide dismutase (SOD) and malondialdehyde (MDA) were observed in various times after Pit injection. Results HDDP could significantly lower the height of T waves, increase SOD activity and decrease MDA content. Conclusion HDDP can improve acute myocardium ischemia induced by Pit.

关 键 词：黄芪丹参滴丸 药理学 心肌缺血 中药疗法 疾病模型 动物 垂体后叶素 

分 类 号：R285.5[医药卫生—中药学]