正交设计多指标综合评分法优化救心速释片处方  

Optimization of formulation of Jiuxin Immediate-Release Tablet by orthogonal design

作　　者：王宁 王建新[2] 宋崎[2] 黄大唯[2] 宋英[2] 周小初[2] 

机构地区：[1]上海雷允上药业有限公司,上海200001 [2]上海市中药研究所,上海200127

出　　处：《中成药》2003年第3期179-182,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :优化中药制剂救心速释片处方 (麝香、人参 ) ,制备中药口服固体速释制剂。方法 :以颗粒的流动性、片剂的崩解时间、片剂的硬度和片剂中有效成分的溶出速度为指标 ,采用正交设计综合评分法优化干法制粒制备救心速释片的处方和制备工艺。结果 :优化所得处方为微晶纤维素 30 % ,羟丙纤维素 1 0 % ,羧甲基淀粉钠 5 % ,糊精约 2 5 %。以此处方制备的救心速释片在崩解时间为 31s,硬度为 38N ,有效成分的溶出速度参数T50 为 2 .1 6min。结论 :优化所得处方合理稳定 ,救心速释片具有明显的速释特征。Objective: To optimize the formulation of Jiuxin Immediate Release Tablet (Moschus, Radix Ginseng). Methods: Jiuxin Immediate Release Tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices. Results: The optimized formulation contained 30% microcrystalline cellulose, 10% L hydroxypropyl cellulose, 5% sodium carboxymethyl starch and 25% dextrin. The hardness, the disintegrating time and T 50 of the tablet were 38N, 31s and 2.16min, respectively. Conclusion: It is successful to prepare Jiuxin Immediate Release Tablet.

关 键 词：救心速释片 正交设计综合评分法 制备工艺 

分 类 号：R944.4[医药卫生—药剂学]