五加皮总苷的抗衰老作用研究  

An Experimental Study of the Antisenility Effect of Total Glycosides of Acanthopanax Bark

作　　者：谢世荣 黄彩云[1] 黄胜英[1] 

机构地区：[1]大连大学医学院药理教研室,116622

出　　处：《医药导报》2003年第4期226-228,共3页Herald of Medicine

摘　　要：目的 :研究五加皮总苷 (TSAB)的抗衰老作用。方法 :小鼠和大鼠共 160只 ,分成 16组 ,每组 10只 ,分别给予TSAB 10 ,2 0mg·kg 1 与人参水提液 60 0mg·kg 1 以及 0 .9%氯化钠 (NaCl)溶液 ,观察小鼠游泳耐力、耐常压缺氧能力、耐寒能力和大鼠过氧化脂质生成的改变。结果 :TSAB 10 ,2 0mg·kg 1 与人参水提液 60 0mg·kg 1 作用相似 ,能明显延长小鼠游泳时间及在常压缺氧和寒冷条件下的生存时间。TSAB也能显著抑制中老龄大鼠体内过氧化脂质的生成。结论Objective:To study the antisenility effect of total glycosides extracted from acanthopanax bark(TSAB). Methods:120 mice as well as 40 rats were separately divided randomly into 16 groups, with 10 animals in each group. The rodents were given each 10, 20 mg·kg 1 of TSAB, 600 mg·kg 1 of aqueous extract of ginseng (AEG) and 0.9% NaCl solution, respectively. Swimming stamina, tolerance to hypoxia under ordinary atmospheric pressure and cold resistance in mice, as well as changes in the production of lipid peroxides(LPO) in rats were kept under observation. Results:TSAB at doses of 10 and 20 mg·kg 1 was shown to have effects similar to those of AEG at a dose of 600 mg·kg 1 including striking prolongation of the time of swimming and extension of the survival time under conditions of hypoxia and cold in mice. TSAB was also found to exert a dramatic inhibitory effect on the production of LPO in middle aged and senile rats. Conclusion:The results of the experiments suggest that TSAB has a prominent antisenility effect.

关 键 词：五加皮总苷 抗衰老 脂质过氧化物 生存时间 

分 类 号：R282.71[医药卫生—中药学] R977.9[医药卫生—中医学]