复方珍珠虫草胶囊治疗慢性乙型肝炎75例  

75 Patients with Chronic Hepatitis B Treated with Compound Zhenzhuchongcao Capsules

作　　者：韩大正[1] 刘春霞[1] 王运杰 

机构地区：[1]河南大学第一附属医院消化内科,开封475001 [2]河南省长垣县人民医院消化内科,453400

出　　处：《医药导报》2003年第4期240-241,共2页Herald of Medicine

摘　　要：目的 :观察复方珍珠虫草胶囊治疗慢性乙型肝炎 (乙肝 )肝纤维化的疗效。方法 :将 12 4例慢性乙肝患者分为两组 ,治疗组 75例 ,对照组 49例。治疗组服用复方珍珠虫草胶囊每次 4粒 ,bid ;对照组服用乙肝宁冲剂 6g ,tid。疗程均为 6个月。观察临床症状、肝功能、肝脏病理组织学及血清 4项纤维化指标变化情况。结果 :治疗组临床症状明显改善率及ALT复常率分别为 64 .3 %和 91.0 % ,对照组分别为 3 4.2 %和 2 0 .1% (P <0 .0 5 ) ;4项纤维化指标治疗组均显著降低 (P <0 .0 1) ,对照组无显著改善 (P >0 .0 5 ) ;肝脏组织学方面 ,治疗组炎症及纤维化均获显著改善 (P <0 .0 5 ,P <0 .0 1) ,对照组无显著改善。结论 :复方珍珠虫草胶囊可使慢性乙肝炎症改善 ,纤维化程度减轻 。Objective:To survey the curative effect of compound zhenzhuchongcao capsules in the treatment of chronic hepatitis B associated with liver fibrosis. Methods:124 patients with chronic hepatitis B were randomly divided into two groups. 75 patients of the treatment group were given each 4 capsules of compound zhenzhuchongcao b.i.d. PO while 49 patients of the control group were treated t.i.d. with yiganning to be taken after being infused in boiling water. The course of treatment in both groups lasted 6 mon. Changes in the pathological histology of the liver and the 4 serum indices reflecting hepatic fibrosis were kept under observation. Results:The rates of dramatic improvement in clinical symptoms and serum ALT normalization in the treatment group were 64.3% and 91.0%, respectively, while those in the control group were 34.2% and 20.1%( P <0.05), respectively. The levels of the 4 serum indices in the treatment group were significantly lowered( P <0.01), while those in the control group showed no evident improvement( P >0.05). As to the pathologic histology of the liver, striking amelioration in inflammation and fibrosis ( P <0.05, P <0.01) was demonstrated in the treatment group, while no apparent inprovement was shown in the control group. Conclusion:Compound zhenzhuchongcao capsules were shown to be fairly effective in improving clinical symptoms and mitigating hepatic fibrosis in patients with chronic hepatitis B.

关 键 词：复方珍珠虫草胶囊 慢性乙型肝炎 纤维化 中医药治疗 

分 类 号：R259.126.2[医药卫生—中西医结合]