海洛因依赖者戒毒前后免疫功能的变化  

Dynamic Changes in the Immune Function of Heroin Dependents Before and After Abstinence

作　　者：马杰[1] 田翼[1] 芦宗正[1] 

机构地区：[1]湖北省新华医院检验科,武汉430015

出　　处：《医药导报》2003年第4期245-246,共2页Herald of Medicine

摘　　要：目的 :观察海洛因依赖者的免疫功能状态 ,并探讨戒毒后其免疫功能的改变。方法 :收集 60例海洛因依赖者 (海洛因依赖组 )和 70例健康人 (对照组 )血液 ,测定外周血T淋巴细胞亚群、IL 2、IL 4、IFN γ、sIL 2R、IgA、IgG、IgM和C3、C4等的水平 ,并进行比较分析。结果 :同对照组相比 ,海洛因依赖者的CD3、CD4 、CD4 CD8显著下降 (P <0 .0 1) ,IL 2和IFN γ水平降低而IL 4水平增高 (P <0 .0 1) ,IgG、C3和C4均大幅减少 (P <0 .0 1)。戒毒后的 2～ 3个月时 ,上述 9项指标均有所恢复 (P <0 .0 5 ) ,但CD4 、CD4 CD8、IL 2和IFN γ仍未达到正常 (P <0 .0 5 )。结论 :海洛因依赖者的体液免疫和细胞免疫都有明显受损 ,并存在Th1 Th2 的失衡。脱毒后的 2～ 3个月内 ,免疫功能虽然趋向于恢复 ,但仍处于低下状态。Objective:To study the state of immune functions of heroin dependents and changes in these functions after abstinence. Methods:Peripheral blood was taken respectively from 60 heroin dependents (abstinence group) and 70 healthy subjects (control group) for determination of T lymphocyte subsets, interleukin(IL) 2, IL 4, interferon (IFN) γ, soluble interleukin 2 receptor (sIL 2R), IgA, IgG, IgM, C3 and C4. Results:In comparison with the healthy controls, heroin dependents were shown to have a significant decrease in the number of CD 3 and CD 4 cells as well as the ratio of CD 4/CD 8 ( P <0.01). Heroin dependents had also lower level of IL 2 and IFN γ but higher level IL 4 ( P <0.01). Besides, they showed a striking reduction in IgG, C3 and C4 ( P <0.01). 2～3 months after abstinence, recovery to some extent happened to all the ten parameters ( P <0.05) except that CD 4, CD 4/CD 8, IL 2 and IFN γ still remained abnormal ( P <0.05). Conclusion:A significant impairment of both cellular immunity and humoral immunity in heroin dependents was demonstrated, including an unbalanced Th 1/Th 2 ratio. Within 2～3 months after abstinence, althongh their immune function tended to recover, it still remained at a low level. More attention should be paid clinically to such a population of people during a relatively long period of time.

关 键 词：海洛因 细胞免疫 体液免疫 TH1/TH2 

分 类 号：R996[医药卫生—毒理学] R446.6[医药卫生—药学]