注射用阿昔洛韦与头孢拉定配伍的稳定性考察  

A Study of the Stabilility of Compatibility of Aciclovir Sodium for Injection and Cefradine in Normal Saline

作　　者：商国美[1] 俞佳[1] 方顺干[1] 王贵发[1] 

机构地区：[1]浙江省人民医院药剂科,杭州310014

出　　处：《医药导报》2003年第4期272-274,共3页Herald of Medicine

摘　　要：目的 :考察 (2 5± 5 )℃下 ,注射用阿昔洛韦与头孢拉定在 0 .9%氯化钠注射液 (NS)中的配伍稳定性。方法 :采用反相高效液相色谱法测定注射用阿昔洛韦与头孢拉定在NS中配伍 18h内各时间段的含量、pH值及微粒数 ,同时观察外观性状变化。结果 :两药配伍后 8h内含量均在 98%以上 ,18h时 ,两药含量略有下降 ,外观颜色略显微黄 ,pH值、微粒数无明显改变。结论Objective:To examine the stability of compatibility of aciclovir sodium for injection and cefradine in normal saline(NS) at 25±5℃. Methods:Reversed phase high performance liquid chromatography method was used to determine the contents of aciclovir sodium and cefradine in NS at various time periods within 18 h. The outward character of the solution was kept under observatien and the pH and number of particles were determined. Results:When aciclovir sodium and cefradine were mixed in NS for less than 8 h, the contents of both drugs were higher than 98%. However, at the 18 th h, the contents of the two drugs were slightly reduced, and the colour of the solution turned light yellow. No obvious changes were found in pH and number of particles. Conclusion:Aaciclovir sodium for injection and cefradine were shown to be compatible within 8 h when mixed in NS.

关 键 词：阿昔洛韦 头孢拉定 配伍 稳定性 高效液相色谱法 

分 类 号：R978.7[医药卫生—药品] R978.11[医药卫生—药学]