二对氯苯甲酰莲心碱对实验性心律失常的影响  

Effects of Di-p-Cl-benzoyl-linesinine on experimental arrhythmia

作　　者：王辉[1] 罗顺德[1] 杨健[1] 

机构地区：[1]武汉大学人民医院药学部,武汉430060

出　　处：《中国药理学通报》2003年第3期306-308,共3页Chinese Pharmacological Bulletin

基　　金：湖北省自然科学基金资助课题NoSJ 98B78

摘　　要：目的　研究二对氯苯甲酰莲心碱抗心律失常的药理作用。方法　采用乌头碱、哇巴因、氯化钙 3种抗心律失常模型。结果　二对氯苯甲酰莲心碱 5mg·kg-1iv可明显提高乌头碱致大鼠、哇巴因致豚鼠发生室性早搏、室性心动过速、室颤及心脏停搏用量 ;延长氯化钙诱发大鼠心律失常的出现时间 ,减少早搏、室颤的发生率及死亡率。AIM The purpose is to study the effect of Di p Cl benzoyl linesinine on experimental arrhythmias. METHODS The models used were caused by aconitine, ouabain and CaCl 2 repectively. RESULTS Di p Cl benzoyl linesinine 5 mg·kg -1 could increase the threshold dose of ventricular ectopic(VE), ventricular tachyacardia(VT), ventricular fibrillation(VF) and cardiac arrest(CA) caused by aconitine in rats and that by ouabain in ginuea pigs; delay the onset time of arrhythmia and decrease the incidence of VE,VF and CA induced by CaCl 2 in rats. CONCLUSION Di p Cl benzoyl linesinine possesses extensive effects of antiarrhythmia on ventricle.

关 键 词：二对氯苯甲酰莲心碱 心律失常 乌头碱 哇巴因 氯化钙 

分 类 号：R541.7[医药卫生—心血管疾病]