Cu(phen)_2^(2+)-H_2O_2-6-巯基嘌呤化学发光体系测定6-巯基嘌呤  

DETERMINATION OF 6-MERCAPTOPURINE WITH Cu(PHEN)_2^(2+)-H_2O_2-6-MERCAPTOPURINE SYSTEM BY CHEMILUMINESCENCE METHOD

作　　者：朱英贵[1] 沐小龙[1] 王伦[1] 王圣庆[1] 

机构地区：[1]安徽师范大学化学与材料科学学院,安徽芜湖241000

出　　处：《安徽师范大学学报（自然科学版）》2003年第1期43-44,47,共3页Journal of Anhui Normal University(Natural Science)

摘　　要：基于 6 -巯基嘌呤 (6 -MP)对Cu(phen) 2 +2 -H2 O2 体系化学发光具有较强的抑制作用 ,建立了化学发光测定 6 -MP的新方法 .该方法线性范围为 2 .0× 10 - 7- 9.0× 10 - 6 g/mL ,检出限为6 .2× 10 - 8g/mL ,对 1.0× 10 - 6 g/mL 6 -MP7次平行测定的相对标准偏差为 2 .9% ,用于药物乐疾宁中 6 -MP的测定 ,回收率为 95 - 10 3% 。A chemiluminescence(CL) suppression for the determination of 6-Mereaptopurine(6-MP) based on Cu(phen) 2+ 2-H 2O 2-6-MP system was established. The linear range for 6-MP 2.0×10 -7 -9.0×10 -6 g/mL and the detection limit is 6.2×10 -8 g/mL. The relative standard deviation(n=7) is 2.9% for 1.0×10 -6 g/mL 6-MP. The method has been applied to the determination of 6-MP in tablets with recovery between 95%-103% and satisfactory results.

关 键 词：H2O2 化学发光体系 6-巯基嘌呤 Cu(phen)2^2+ 抗癌药物 乐疾宁 测定方法 

分 类 号：R979.1[医药卫生—药品] R927.2[医药卫生—药学]