复方中药健脾丸和保和丸对小鼠胃肠运动的影响  

Effects of Chinese herb complex Jianpiwan and Baohewan on gastrointestinal motility in rats

作　　者：刘欣[1] 郅敏[1] 雷莉[1] 龚均[1] 聂丹丽[2] 陈松盛[1] 董蕾[1] 

机构地区：[1]西安交通大学第二医院消化内科,陕西省西安市710004 [2]西安交通大学第二医院中医科,陕西省西安市710004

出　　处：《世界华人消化杂志》2003年第1期54-56,共3页World Chinese Journal of Digestology

基　　金：国家自然科学基金;No.30170414~~

摘　　要：目的:观察传统的消食导滞方剂保和丸和健脾丸对小鼠胃肠运动功能的影响.方法:以胃肠内标记物葡聚糖蓝-2000在胃内色素残留量及小肠推进比为指标,观察各实验组对正常脾虚模型小鼠胃排空及肠推进的影响.结果:保和丸、健脾丸对正常小鼠及脾虚模型小鼠的胃排空均起到明显的促进作用0.029±0.033vs0.059±0.035;0.018±0.010vs0.059±0.035;0.036±0.028vs0.089±0.042;0.029±0.026vs0.089±0.042.(P<0.05);对正常小鼠的肠推进运动的促进作用,保和丸则更优于健脾丸58.8±11.3vs51.6±9.7,(P<0.05).对肠蠕动功能增强的“脾虚”模型小鼠的肠推进运动,保和丸仍有促进作用63.5±6.1vs54.1±12.3,(P<0.05),而健脾丸则可调节使其减慢而恢复正常43.0±7.1vs54.1±12.3,(P<0.05).结论:保和丸及健脾丸对胃肠运动功能可起到促进及调节作用.AIM:To investigate the effects of Jianpiwan and Baohewan on gastrointestinal motility in rats. METHODS:Using dextran blue 2000 as a gastrointestinal internal marker its relative remaining rate in stomach and its pushing ratio of the bowel, we observed the effects of Jianpiwan and Baohewan on the emptying of stomach and the driving of bowel in normal and splenic asthenic rats. RESULTS:Baohewan and Jianpiwan had evidently promot- ing effect on emptying of stomach in normal and splenic asthenic rats 0.02.9±0.03.3 vs 0.05.9±0.03.5; 0.018±0.010 vs 0.059±0.035; 0.036±0.028 vs 0.089±0.042; 0.029±0.026 vs 0.089±0.042(P <0.05). Baohewan had better effect than Jianpiwan on the driving of bowel in normal rats 58.8±11.3 vs 51.6±9.7 (P <0.05).For splenic asthenic rats whose ver- miculation was reinforced,Baohewan still had promoting ef- fect 63.5±6.1vs 54.1±12.3, (P <0.05) and Jianpiwan can slow the vermiculation and help it recover to normal leves 43.0±7.1 vs 54.1±12.3 (P <0.05). CONCLUSION:Baohewan and Jianpiwan have promoting and adjusting effects on gastrointestinal motility in rats.

关 键 词：复方中药健脾丸 保和丸 小鼠 胃肠运动 

分 类 号：R285.5[医药卫生—中药学]