阿仑膦酸钠对骨小梁力学特性的作用  

Effects of alendronate on trabecular bone mechanical properties

作　　者：胡建华[1] 张良[1] 孙常太[1] 黄公怡[1] 

机构地区：[1]北京医院骨科,100730

出　　处：《中国骨质疏松杂志》2003年第1期61-63,共3页Chinese Journal of Osteoporosis

摘　　要：目的　评价阿仑膦酸钠对骨小梁力学特性的作用。方法　选取成年雌性Hound犬 16只 ,随机分成两组 ,实验组 8只 ,口服阿仑膦酸钠 ,剂量为 0 5mg·kg-1·d-1,另选 8只作为对照组。 12周后处死 16只犬并收集其L1和L2 标本 ,进行压缩试验计算腰椎力学参数。结果　实验组在服用阿仑膦酸钠后其杨氏模量在样本头尾 (CC)、前后 (AP)和左右 (LR)方向上分别增加了 18 5 %、2 7 8%和3 3 1%。与对照组相比 ,实验组极限应力、骨折能量和头尾方向上的杨氏模量显著增加。结论　口服阿仑膦酸钠 ,剂量为 0 5mg·kg-1·d-1时 ,进行短期治疗能增强犬科骨小梁的力学特性。Objective To evaluate the effects of alendronate on trabecular bone mechanical properties Methods Alendronate was administered at a daily oral dose of 0 5 mg/kg over a 12 week period in hound dogs ( n =8+8 for control and treated groups) Mechanical indices of the lumbar vertebral (L 1 and L 2) trabecular bone were assessed directly from compression testing Results Treatment with alendronate increased Young's modulus by 18 5%, 27 8% and 33 1%, respectively,in the cephalo caudal(CC), antero posterior (AP) and left right (LR) directions Ultimate stress,failure energy and Young's modulus CC for the alendronate treated group were significantly increased, comparted with that of the control group Conclusion Alendronate increases the mechanical properties of canine trabecular bone after short-term treatment at a dose of 0 5 mg·kg -1 · day -1 Thus, alendronate can increase the mechanical properties of healthy trabecular bone in a short-term period

关 键 词：阿仑膦酸钠 骨小梁 力学特性 骨质疏松 

分 类 号：R681[医药卫生—骨科学]