伴高促性腺激素继发闭经的细胞遗传学研究  

A study of hypergonadotropic secondary amenorrhea with cytogenetics

作　　者：张静[1] 唐吟宇[1] 郭玉萍[1] 

机构地区：[1]重庆医科大学基础医学院生物学教研室,重庆400016

出　　处：《重庆医科大学学报》2003年第2期151-152,共2页Journal of Chongqing Medical University

摘　　要：目的 :探讨卵巢早衰的发病原因。方法 :采用细胞遗传学的方法 ,对 10 4例高促性腺激素继发闭经的患者作外周血淋巴细胞染色体检查。结果 :发现 13例患者有性染色体数目或结构异常 ,占总数的 12 .5 %。其中X染色体数目异常 3例 ,X染色体结构异常 10例。结论 :本文的研究结果提示X染色体长臂末端可能是卵巢早衰的特异性基因区段并与X染色体末端端粒的缺失有关。Objective:To explore the etiology of premature ovarian failure. Methods: 104 cases of hypergonadotropic secondary amenorrhea were studied cytogenetically. Results: The incidence of chromosomal abnormalities was 12.5%(13/104).Among them,3 cases were numeral abnormalities of X chromosome and 10 cases were structural abnormalities of X chromosome.Conclusion: The result showed that terminal deletion of Xq and telomeric deletion of X chromosome were important factors of premature ovarian failure.

关 键 词：卵巢早衰 X染色体 端粒 

分 类 号：R711.51[医药卫生—妇产科学]