应激大鼠室旁核神经元c-fos的表达  

EXPRESSION OF C-FOS IN PARAVENTRICULAR NUCLEUS OF RATS IN STRESS STATE

作　　者：宋海英[1] 朱玉红[2] 马云[3] 

机构地区：[1]滨州医学院护理系,滨州市256603 [2]滨州医学院附属医院病理科 [3]滨州医学院病理教研室

出　　处：《滨州医学院学报》2003年第2期83-84,共2页Journal of Binzhou Medical University

摘　　要：目的 :为下丘脑室旁核参与应激反应提供形态学资料。方法 :以铃声刺激大鼠为应激动物模型 ,用免疫组织化学 ABC法显示下丘脑室旁核神经元即早基因 c- fos的表达。结果 :铃声刺激使鼠室旁核神经元 ,尤其是小细胞亚核神经元 c- fos表达显著增加。结论 :下丘脑室旁核神经元在铃声刺激下处于活动状态 ,参与应激反应。Objective:To investigate morphological basis for the hypothalamic paraventricular nucleus (PVN) responding to stress.Methods:The c fos of in PVN rats stimulated by the sound of an electric generator was determined by immunohistochemical ABC method.Results:The expression of c fos increased significantly in PVN of stimulated rats,especially in the parvicellular subnucleus of PVN.Conclusion:The neurons of PVN were activated during stress,which suggested that PVN took part in response to stress.

关 键 词：下丘脑 应激 大鼠 室旁核 神经元 C-FOS 基因表达 

分 类 号：R338.27[医药卫生—人体生理学]