年轻人冠心病危险因素分布及聚集状况  

Clustering status of coronary heart disease risk factors in young men

作　　者：刘晓宁[1] 张春玲[1] 武文君[1] 惠汝太 高润霖[2] 陈纪林[2] 杨跃进[2] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院中德分子医学研究室,北京100037 [2]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院冠心病研究室,北京100037

出　　处：《中华心血管病杂志》2003年第2期87-90,共4页Chinese Journal of Cardiology

摘　　要：目的　观察年轻人中冠心病危险因素的分布及聚集状况 ,为早期年轻人防治冠心病提供依据。方法　选择年轻冠心病患者 (经冠状动脉造影证实 ,年龄≤ 40岁 ) 1 78例作为疾病组 ,并以年龄匹配的冠状动脉造影正常的年轻人 70例作为对照组 ,分析了传统危险因素 (高血压、高血糖、高血脂、肥胖、吸烟史、家族史 )和新危险因素同型半胱氨酸 (HCY)、脂蛋白 (a)、小而密低密度脂蛋白、C反应蛋白 (CRP)在两组间的变化特点及聚集情况。结果　 (1 )在传统的危险因素中 ,疾病组的甘油三酯(TG)和胆固醇 (TC)水平、吸烟和家族史的比率明显高于对照组 (P <0 0 5) ;在新的危险因素中 ,疾病组的血浆HCY(2 1 66± 1 8 2 2 ) μmol L和CRP(5 78± 6 90 )mg L比对照组的血浆HCY(1 4 94± 8 97)μmol L和CRP(2 87± 2 0 0 )mg L明显增高 (P <0 0 1 ) ,其他危险因素在两组间比较差异无显著性。(2 )疾病组与对照组比较 ,有危险因素者明显增多 (P <0 0 5) ,2种以上新危险因素聚集增加 ,3种新危险因素聚集比较差异有显著性 (P <0 0 5) ,传统危险因素聚集性比较差异无显著性。 (3)logistic回归显示吸烟 (OR值为 2 4,95 %CI:1 31 5～ 4 2 75)、TG(OR值为 1 8,95 %CI:1 2 1 5～ 2 541 )、HCY(OR值为 1 9,95 %CI:1 0Objective The purpose of this study was to investigate the clustering status of risk factors for coronary heart disease (CHD) in the young and analyze the relationship of risk factors with CHD. Methods One hundred seventy eight young patients with CHD(documented angiographically) aged under 40 and 70 age matched non CHD young individuals (angiographically normal) as control were recruited. Their plasma levels of homocysteine (HCY), lipoproteina, small dense LDL, C reactive protein(CRP) and traditional risk factors(hypertension, hyperlipidemia, diabetes, obesity, smoking) were evaluated . Results (1) The levels of HCY?CRP?TC?TG, the rate of smoking and family history were significantly higher in young CHD group than those in control group ( P <0.05). (2) The frequencies of risk factors and clustering of any three new risk factors in young CHD group were remarkably higher than those in young non CHD group ( P <0.05).(3)Multiple logistic regression analysis showed that close relationships exist between CHD and smoking ( OR =2.4, 95% CI :1.315 4.275),TG ( OR =1.8,95% CI :1.215 2.541),HCY ( OR =1.9, 95% CI :1.060 3.527) and CRP ( OR = 2.9, 95% CI :1.303 6.289) by adjustment for other risk factors. Conclusion The smoking, TG, HCY and CRP are important CHD risk factors for young people. The clustering status of new risk factors were associated with CHD in Chinese young population.

关 键 词：年轻人 冠心病 危险因素 分布 聚集状况 

分 类 号：R541.4[医药卫生—心血管疾病]