乌三颗粒对肿瘤新生血管形成的干预作用及机制研究  

Inhibitory effect and mechanism of Wusan Granule (乌三颗粒) on tumor angiogensis

作　　者：石锦萍 杨红[2] 周毅[3] 董丹丹[2] 李科[2] 藏志和[1] 辛志伟[1] 高丽元 沈映君[3] 黄秀凤[3] 

机构地区：[1]第三军医大学成都军医学院人体结构教研室,成都610083 [2]四川省人民医院病理科 [3]成都中医药大学

出　　处：《中药药理与临床》2003年第1期22-24,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：重庆科委立题课题 (1 999);四川省教委青年基金重点课题 (2 0 0 0 A71 )

摘　　要：目的 :探讨乌三颗粒对肿瘤新生血管形成的干预及干预机制。方法 :采用免疫组织化学染色法 ,病理彩色图像定量分析法 ,对各小鼠S180 肉瘤组织进行MVD、VEGF和bFGF表达的检测。结果 :乌三颗粒能明显下调MVD、VEGF和bFGF的表达。结论 :乌三颗粒对肿瘤新生血管的形成有明显干预作用 ,这可能是乌三颗粒抗肿瘤的重要途径之一。Objective: To study inhibitory effect and mechanism of Wusan Granule on tumor angiogensis. Methods: The expression of MVD?VEGF and bFGF in S 180 sarcoma were studied by using immunohistochemistry, and were assessed by computer image analysis system. Results: The expression of MVD?VEGF and bFGF were decreased significantly by treatment of Wusan Granule, compared with the control group. Conclusion: Wusan Granule can obviously inhibit the tumor angiogensis and it is the one of pathways on anti tumor of Wusan Granule.

关 键 词：乌三颗粒 干预作用 S180肉瘤 新生血管形成 中药 药理 

分 类 号：R285.5[医药卫生—中药学]