肾素和血管紧张素Ⅱ在急性胰腺炎大鼠病程演变中的作用  

The role of rennin and angiotension Ⅱ in the developement of acute pancreatitis in rats

作　　者：胡铭荣[1] 徐德征[1] 王雄[1] 陆伟伟[1] 江素君[1] 

机构地区：[1]浙江省杭州市第二人民医院普外科,浙江杭州310015

出　　处：《中国现代普通外科进展》2003年第1期22-24,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的 :探讨肾素、血管紧张素Ⅱ在急性胰腺炎病程演变中的作用。方法 :42只SD大鼠分急性胰腺炎组和对照组。对照组仅作胃窦切开缝合术 ,急性胰腺炎组用十二指肠闭襻法复制急性胰腺炎模型 ,在病程不同时点测定血浆淀粉酶、血浆肾素活性、血管紧张素Ⅱ水平 ,并观察胰腺组织病理学改变。结果 :( 1)急性胰腺炎组随着病变的进展 ,血浆淀粉酶升高 ;病程 10h时胰腺炎病理呈水肿性改变 ,2 4h时呈出血坏死性改变 ;病程 2 4h胰腺组织病理学评分显著高于 10h(P <0 .0 5 )。 ( 2 )急性胰腺炎组血浆肾素活性在病程 10h时显著高于对照组 (P <0 .0 1) ,在 2 4h时略高于 10h,但差别无统计学意义 (P >0 .0 5 )。 ( 3 )急性胰腺炎组血浆血管紧张素Ⅱ水平在病程 10h、2 4h时均显著高于对照组 (P<0 .0 5 ,P <0 .0 1) ,2 4h又显著高于 10h(P <0 .0 5 )。结论 :肾素。Objective:To study the role of rennin and angiotension Ⅱ in the developement of acute pancreatitis in rats.Methods:Forth-two Sprague-Dawley rats were divided into two groups randomly-control group,and acute pancreatitis group.Acute pancreatitis model was reproduced by closed duodenal loop technique.Plasma amylase.Plasma renin activity and angiotesion Ⅱ level were measured,pancreatic histopathology was examined with light microscopy. Results:In acute pancreatitis group,pancreatitis histopathology developed from edematous to bleeding and necrotizing pancreatitis,plasma amylase,plasma renin activity,and angiotesion Ⅱ level were increased as acute pancreatitis developed,but after 10h,the angiotesion Ⅱ level was increased sequentially and plasma renin activity was increased unsignificantly.Conclusion:Renin and angiotension Ⅱ played the important role in the developement of experimental acute pancreatitis.

关 键 词：胰腺炎 肾素 血管紧张素Ⅱ 

分 类 号：R657.51[医药卫生—外科学]