农药甲霜灵对映体的高效液相色谱分离及手性拆分热力学研究  

Enantioseparation and Study of Thermodynamical Property of Metalaxyl on a Polysaccharide-Based Chiral Column by High Performance Liquid Chromatography

作　　者：侯经国[1] 孟晓荣[1] 何天稀[1] 邓华陵[1] 毛学峰[1] 韩小茜[1] 高锦章[1] 

机构地区：[1]西北师范大学化学化工学院,兰州730070

出　　处：《分析化学》2003年第3期307-310,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金 (No .2 9775 0 19);西北师范大学科技创新基金 (KJCX 0 0 1)资助项目

摘　　要：以正己烷 异丙醇为流动相 ,在纤维素 三 (3 ,5 二甲基苯基氨基甲酸酯 ) (CDMPC)涂敷型手性固定相上 ,对农药甲霜灵外消旋体进行了拆分 ,考察了流动相组成、柱温等对甲霜灵对映体的保留和分离的影响 ;对甲霜灵R。A new chiral agrochemicals, metalaxyl, has been resolved under normal phase chromatography by using cellulose tris(3,5-dimethylphenylcarbamate) chiral column (CDMPC-CSP). The effects of chromatographic conditions such as mobile phases, flow rate, length of column and temperature to chiral recognition of the metalaxy have been investigated. The thermodynamical parameters of enantioseparation of the metalaxyl on CDMPC-CSP chiral column have also been determined. The results obtained are important for the determination and quality control of the metalaxy in industrial process.

关 键 词：农药 甲霜灵 分离 手性拆分 热力学 高效液相色谱 手性固定相 对映体拆分 杀菌剂 

分 类 号：TQ450[化学工程—农药化工]