孕妇对新生儿体内的GBSⅢ型特异性抗体水平影响的研究  

The Study of Pregnant Women's Influence to the Level of Special Antibody-GBSⅢ Type of Newborns

作　　者：杨华[1] 薛晓萍[2] 张保宏[3] 常黎华[4] 

机构地区：[1]西安交通大学第二医院妇产科,陕西西安710004 [2]西安财经学院医院,陕西西安710061 [3]西安交通大学第二医院检验科,陕西西安710004 [4]西安交通大学第二医院外一科,陕西西安710004

出　　处：《中国儿童保健杂志》2003年第2期99-101,共3页Chinese Journal of Child Health Care

摘　　要：【目的】　探讨孕妇体内B组溶血性链球菌 (GBS)Ⅲ型抗体对新生儿体内该抗体的影响。　【方法】　随机选择 10 2例健康孕妇 ,取静脉血 ,分娩时取脐血 ;并选取其中 62例足月正常新生儿 ,出生后 2～ 7d取静脉血。用酶联免疫实验 (ELISA)检测GBSⅢ型特异性抗体。　【结果】　孕妇体内GBSⅢ型抗体水平平均为 2 2 .47mg/L ,新生儿脐血该抗体平均水平 17.90mg/L ,二者之间密切相关 (r =0 .80 ,P <0 .0 1) ,后者随着胎龄的增加而增加 ;日龄 2～7d新生儿静脉血该抗体水平平均为 14 .85mg/L ,三组之间的差异有显著性 (P <0 .0 5 )。 　【结论】　①所检测的GBSⅢ型抗体值绝大多数 >2mg/L ,提示西安地区孕妇获得抗体水平较高 ,对新生儿GBS感染提供保护作用。②新生儿体内该抗体来源于母体 ,随着出生时间的延长而降低。③新生儿脐血该抗体含量与母亲静脉血含量有关 ,且随着胎龄增加而增加 ,提示该抗体与胎盘主动运转有关。早产儿由于从母体获取保护性抗体较低而易于感染GBS。To discuss the influence of antibody of GBS Ⅲ type about mothers to their newborns. 102 health pregnant women were elected randomly; their vein blood and their fetus umbilical blood, and 62 normal newborn vein blood (aged 2～7 days) were drawn. The levels of antibody-GBS Ⅲ were detected by ELISA technique. The level of average antibody GBSⅢ was 22.47mg/L in pregnant women; 17.90mg/L in fetus umbilical blood. It was related closely between the two samples; the latter one was increased with their pregnant weeks. The level of average antibody in 2～7 day newborns was 14.85 mg/L. There were prominent differences among three groups. [Conclusions] ① Most of osculate values of antibody for GBS Ⅲ type went beyond the 2 mg/L; It hinted that the levels of antibody for pregnant women were higher in Xi'an area. The antibody offers a protective function to newborn's infection.② The antibody of newborn came from their mothers, and its levels were reduced with newborn's age.③ The value of antibody in fetus umbilical blood was related to that in mother's vein blood; and it increased with pregnant weeks. It hinted that the antibody was related to active transportation of placenta. Premature fetuses were easy to infect GBS because of lower protective antibody acquired by their mothers.

关 键 词：链球菌 抗体 孕妇 新生儿 

分 类 号：R174.6[医药卫生—妇幼卫生保健]