MYS2多态位点在中国26个人群中分布的研究  

THE DISTRIBUTION OF MYS2 POLYMORPHISM IN 26 CHINESE POPULATIONS

作　　者：薛雅丽[1] 包维东[2] 傅松滨[1] Tatiana Zerjal 朱苏玲[2] 徐玖瑾[2] 杜若甫[2] 张贵寅[1] 李璞[1] Chris Tyler-Smith 

机构地区：[1]哈尔滨医科大学生物学教研室,哈尔滨150086 [2]中国科学院遗传学研究所,北京100101 [3]Department of Biochemistry

出　　处：《人类学学报》2003年第1期63-68,共6页Acta Anthropologica Sinica

基　　金：国家自然科学基金重大项目资助 (3999342 0 );英国皇家学会资助项目(Q740 );黑龙江省科技攻关项目资助(G99C19-1-1)

摘　　要：对中国 2 6个人群中Y染色体小卫星位点MYS2的分布进行了研究 ,结果显示 :MYS2 4是常见的等位基因类型 ,MYS2 3在中国不同人群中分布差异很大 (0— 32 4% ) ;并对该位点在不同人群中分布的频率进行了AMOVA分析 ,结果为 :不分组、南方人群和北方人群的遗传学差异分别为 7 76 %、8 1 1 %和 1 42 %。南北方人群间、东北和西北人群间的差异分别为 4 34%和 1 57%。结论 :MYS2是研究中国人群遗传结构有价值的多态位点 ,中国不同人群之间存在一定的遗传学差异 ,中国南方人群间的遗传学差异较大 ,再次证实了中国人群的南北差异。The distribution of MYS2 polymorphism in 26 Chinese populations was analyzed by PCR. And the variations of intra- and between populations were calculated using AMOVA by Arlequin Package. MYS2*4 was the common allele while the incidence of MYS2*3 was much different in these populations. By AMOVA, 7.76%、8.11% and 1.42% of total variation were found among all 26, 10 Southern and 16 Northern Chinese populations respectively. And 4.34% of total variation was found between the Southern and Northern groups while 1.57% was found between northeast and northwest groups. The results showed that MYS2 polymorphism is very useful in analyzing the genetic structure of Chinese population. Some difference in genetic structure was seen among the different populations and a geographical distinction between South and North was confirmed. The distinction between Western and Eastern populations in the Northern China was also suggested.

关 键 词：MYS2多态位点 分布 Y染色体 AMOVA 中国人群 

分 类 号：Q987[生物学—遗传学]