^(153)Sm配合物与牛血清白蛋白结合对骨摄取的影响  

INFLUENCE OF BINDING CHARACTERISTICS OF ^(153)Sm-COMPLEXES TO BSA ON THEIR BONE UPTAKE

作　　者：杨玉青[1] 罗顺忠[1] 王关全[1] 何佳恒[1] 邴文增[1] 蒲满飞[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900

出　　处：《核化学与放射化学》2003年第1期45-48,共4页Journal of Nuclear and Radiochemistry

基　　金：国家自然科学基金资助项目(29971027);中国工程物理研究院核物理与化学研究所所长基金资助项目(703)

摘　　要：研究了NTMP(次氮三亚甲基膦酸),HEDTMP(N (羟乙基)乙二胺基三亚甲基膦酸),DCTMP(1,2 环己二胺四亚甲基膦酸),EDTMP(乙基二胺基四亚甲基膦酸),DTPMP(二乙基三胺基五亚甲膦酸),DTPA(二乙基三胺基五醋酸)的153Sm配合物在羟基磷灰石(HA)和Ⅰ型骨胶原上的吸附及其在小鼠体内的骨摄取,观察到体内骨摄取与体外骨模型吸附性能的差别。在对上述6个153Sm配合物与牛血清白蛋白(BSA)的结合性质研究中观察到,153Sm配合物与BSA的结合性对其骨摄取过程有重要影响,并解释了153Sm配合物体内骨摄取与体外骨模型吸附不一致的原因。The bone uptake in normal mice and adsorption on bone model materials (hydroxyapatite and type I collagen) of 153SmNTMP, 153SmHEDTMP, 153SmDCTMP, 153SmEDTMP, 153SmDTPMP and 153SmDTPA are compared, and then the binding characteristics of these 153Smcomplexes to bovine serum albumin (BSA) are investigated. It is found that there is a discrepancy between the bone uptake and the adsorption on bone model materials, and that the binding characteristics of these 153Smcomplexes to BSA play an important role in the process of their bone uptake. Also, the binding characteristics are applied to explain the discrepancy successfully.

关 键 词：配合物 牛血清白蛋白 骨摄取 骨模型吸附 钐153 药物代谢 骨靶向性药物设计 体内分布 

分 类 号：R969.1[医药卫生—药理学] R982[医药卫生—药学]