氯喹敏感与抗性株恶性疟原虫对青蒿琥酯、克林霉素及其联用的体外敏感性  

Sensitivity of chloroquine sensitive and resistant plasmodium falciparum to artesunate,clindamycin and combinations

作　　者：高白荷[1] 杨恒林[1] 李丽[1] 

机构地区：[1]云南省寄生虫病防治研究所,思茅市665000

出　　处：《中国热带医学》2003年第2期142-144,共3页China Tropical Medicine

基　　金：联合国开发计划暑/世界卫生组织热带病研究与培训特别规划处资助(ID - 971 1 4 4 );中国云南省卫生厅资助项目(NO980 0 7)~~

摘　　要：目的　为了解氯喹敏感和抗性株恶性疟原虫对青蒿琥酯、克林霉素及其二者联用的敏感性。方法　运用Rieckmann体外微量法测定原虫对药物的敏感性。结果　氯喹敏感株恶性疟原虫对青蒿琥酯、克林霉素及青 /克联用的ID50 分别为 2 .8、3 784.7及 6.4/ 2 0 46.6nmol/L ;抗性株原虫对上述药物的ID50 分别为 8.1、165 2 .1及 2 .3 5 / 14 0 9.4nmol/L。结论　抗氯喹恶性疟原虫对克林霉素无交叉抗性。青蒿琥酯与克林霉素联用在体外测定中 。Objective To understand the sensitivity of chloroquine sensitive and resistant p.falciparum isolates to artesunate,clindamycin and combined use of artesunate and clindamycin. Methods Rieckmann's in vitro microtechnique was used. Results ID 50 of artesunate,clindamycin and combined use of artesunate and clindamicin were 2.8,3784.7 and 6.4/2046.6 nmol/L to the sensitive isolates respectively;ID 50 of the drugs as above were 8.1,1652.1 and 2.35/1409.4 nmol/L to the resistant isolates respectively. Conclusion The resistant isolates of p.falciparum has no cross resistance to clindamycin.Artesunate combined with clindamycin has an increasing effectiveness to the resistant isolates in vitro test.

关 键 词：恶性疟原虫 青蒿琥酯 克林霉素 敏感性 体外测定 

分 类 号：R531.3[医药卫生—内科学]