头穴透刺对急性脑梗塞大鼠脑组织中β-EP与cAMP含量的相关性研究  

Correlation Research on Scalp-Point Penetration Needling on β-EP and cAMP in the Brain Tissue of Rats with Acute Cerebral Infarction

作　　者：吴绪平[1] 韩肖华[2] 王亚文[1] 刘又香[1] 

机构地区：[1]湖北中医学院,湖北武汉430061 [2]华中科技大学同济医学院附属同济医院康复医学科,湖北武汉430030

出　　处：《中国中医基础医学杂志》2003年第1期47-49,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：湖北省科委重点科技项目 ( 971P14 0 1)

摘　　要：目的 :探讨头穴透刺对急性脑梗塞大鼠脑组织中 β EP(β Endorphin ,β内啡肽 )与cAMP(cyclicAMP ,环磷腺苷 )含量变化的相关性。方法 :用线栓法直接阻断大鼠大脑中动脉开口处制作急性脑梗塞模型 ,采用放免技术 ,检测头穴透刺对急性脑梗塞大鼠脑组织中 β EP与cAMP含量的影响。结果 :头穴透刺后可使大鼠脑组织中cAMP的含量明显升高 ,使 β EP含量明显降低而趋于正常值 ,两者之间呈显著负相关。结论 :头穴透刺可以调节脑组织中 β EP与cAMP的含量 ,改善梗死脑组织供血 ,这可能是针灸发挥治疗作用的重要机制之一。Objective To research the correlation of scalp-point penetration needling with the content of β-EP and cAMP in the brain tissue of rats with acute cerebral infarction.Methods acute cerebral infarction was produced by blocking blood flow of the middle cerebral artery.After acupuncture,the content of β-EP and cAMP in the brain tissue of rats was observed with radio-immunoassay (RIA).Results After acupuncture,the content of cAMP increased significantly and the content of β-EP lowered evidently and was close to that of normal group.There was significant negative correlation between the content of β-EP and cAMP.Conclusion Scalp-point penetration method can adjust the content of β-EP and cAMP in the brain tissue of rats with acute cerebral infarction and improve the focus of infarct's blood suppls blood supply,w of the important mechanisms of acupuncture treatment.

关 键 词：脑梗塞 头针 透刺 Β-EP CAMP 

分 类 号：R245.32[医药卫生—针灸推拿学]