转化生长因子β_1、Bax多肽在高血压大鼠肾上腺的表达  

The Expression of Transforming Growth Factor β_1 and Bax Polypeptide in Adrenal Gland of Dahl Hypertension Rats

作　　者：潘林洁[1] 王春艳[1] 高福禄[1] 庞晓静[2] 

机构地区：[1]承德医学院组胚教研室,河北承德067000 [2]承德医学院中心实验室,河北承德067000

出　　处：《解剖科学进展》2003年第1期28-30,共3页Progress of Anatomical Sciences

摘　　要：目的　观察Dahl大鼠肾上腺中转化生长因子 β1(TGF β1)、凋亡相关基因Bax多肽表达的动态变化 ,探讨原发性高血压与肾上腺细胞凋亡的关系。方法　应用日本引进的Dahl高血压大鼠 ,SP免疫组织化学方法染色。结果　TGF β1、Bax免疫阳性细胞主要分布于肾上腺髓质 ,阳性反应产物见于细胞质中。TGF β1和Bax的阳性细胞数 ,在盐敏感性高血压 (DahlS)大鼠 ,均随着高血压的进展而有显著提高趋势。结论　TGF β1和Bax在Dahl大鼠肾上腺髓质均有表达 ,随着高血压的病程延长 ,表达逐渐明显升高 。Objective The dynamic changes of transforming growth factor β 1(TGF β 1) and Bax polypeptide in adrenal gland of Dalhl rats was observed to study the relationship between primary hypertension and apoptosis of the cells in adrenal gland. Method The Dahl hypertension rats recommended from Japan were used in this experiment by SP immunohistochemistry. Results The positive cells of TGF β 1 and Bax were mainly distributed in adrenal medulla. The positive product was distributed in cytoplasm. The positive cells of TGF β 1 and Bax were increased significantly with the development of hypertension in the Dahl salt sensitivety(DahlS) hypertension rats compared with the control. Conclusion Both TGF β 1 and Bax may be involved in the apoptosis of adrenomedullary cells.

关 键 词：Dahl高血压大鼠 肾上腺 转化生长因子Β1 Bax多肽 免疫组织化学 

分 类 号：R544.102[医药卫生—心血管疾病]