阿弗菌素产生菌SIPI-AV-99081的选育  

Breeding of Avermectins Producing Strain SIPI-AV-99801

作　　者：冯军[1] 赵文杰[1] 程晴华[1] 林纲[1] 朱裕辉[1] 

机构地区：[1]上海医药工业研究院,上海200040

出　　处：《中国医药工业杂志》2003年第3期118-121,共4页Chinese Journal of Pharmaceuticals

摘　　要：阿弗菌素链霉菌 SIPI-AV-990 81采用 UV和 NTG进行诱变处理 ,选育得到一高产菌株和几个典型的突变株。高产菌株 AV-h-3 60的阿弗菌素 B1 的生产能力较出发菌株提高了 3倍。 AV-m-4 86和 AV-m-796为阿弗菌素合成阻断突变株 。A high yielding strain AV h 360 was obtained by UV irradiation and NTG treatment of SIPI AV 99081. Avermectin B 1 production of strain AV h 360 was 300% higher than that of the original strain. Both mutants AV m 481 and AV m 796 obtained were unable to produce natural avermectins.

关 键 词：阿弗菌素 菌种选育 突变株 

分 类 号：TQ465.5[化学工程—制药化工]