盐酸洛美利嗪及有关物质的HPLC测定  

Determination of Lomerizine Hydrochloride and Its Related Substances by HPLC

作　　者：刘卫卫[1] 吴琼珠[1] 戴永健[1] 乔善磊[1] 

机构地区：[1]第二军医大学南京军医学院药剂教研室,江苏南京210099

出　　处：《中国医药工业杂志》2003年第3期139-140,共2页Chinese Journal of Pharmaceuticals

摘　　要：采用 RP-HPL C法测定盐酸洛美利嗪的含量及其有关物质。色谱柱为 L ichrospher5 C1 8柱 (2 0 0× 4.6mm,5 μm) ,流动相为乙腈 -p H5 .8磷酸盐缓冲液 (80∶ 2 0 ) ,检测波长 2 10 nm。线性范围为 40～ 160 μg/ ml,r=0 .9999,精密度 <2 %。A RP HPLC method for the determination of lomerizine hydrochloride and its related substances was presented. The Lichrospher5 C 18 column(200×4.6 mm, 5 μm)was used, with the mobile phase of acetonitrile phosphate buffer solution (pH5.8)(80∶20), at the detection wavelength of 210 nm. The linear range was 40～160 μg/ml( r =0.9999), RSD <2%.

关 键 词：盐酸洛美利嗪 有关物质 HPLC 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]