膜分离技术在低分子量生物产品分离纯化中的应用  

Membrane Separation Technology and its Application in Purifying and Separating Bio-products with Low Molecular Weights

作　　者：姚红娟[1] 王晓琳[1] 

机构地区：[1]清华大学化学工程系,北京100084

出　　处：《化工进展》2003年第2期146-152,共7页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金项目 (No 2 98760 18);国家"863"项目 ( 2 0 0 1AA32 70 5 0 )

摘　　要：介绍了膜分离技术在低分子量生物产品分离纯化中的应用。以压力差为推动力的膜分离技术包括微滤、超滤、纳滤、反渗透等 ,其分离性能通常由透过通量和截留率表征 ,而操作模式则分为浓缩和渗滤两种。本文将低分子量生物产品划分为氨基酸和多肽、抗生素、乳酸及低聚糖等 ,综述了膜分离技术在上述产品的回收、分离。Membrane separation technology and its applications in purifying and separating bio-products with low molecular weights are reviewed. The pressure-driven membrane processes includes in general the microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). The separation performances of these membranes are usually expressed as the permeation flux and solute rejection, and the operation modes are classified into two kinds, that is,the concentration and diafiltration. In this article, the bio-products are divided into amino acids and peptides, antibiotics, lactic acid and oligosaccharides, and membrane separation technology applied in the recovery, fractionation, purification and concentration of the bio-products are reviewed.

关 键 词：膜分离技术 低分子量 生物产品 分离 纯化 应用 微滤 超滤 纳滤 浓缩 渗滤 

分 类 号：TQ028.8[化学工程] TQ464