北京地区汉族妇女雌激素受体基因XbaI多态性与骨密度和体重指数的关系  

XbaI Polymorphisms of the Estrogen Receptor Gene and Bone Mineral Density and BMI in Beijing Han Women

作　　者：薛延[1] 李东 王芊[1] 董兆文 

机构地区：[1]北京积水潭医院创伤骨科研究所,北京100035 [2]国家计划生育委员会科学技术研究所分子生物学研究室,北京100081

出　　处：《遗传》2003年第2期137-140,共4页Hereditas（Beijing)

基　　金：国家自然科学基金资助项目(39970660)

摘　　要：为探讨北京地区汉族妇女雌激素受体(ER)基因XbaI多态性与骨密度的关系,采用双能X线吸收仪检测腰椎、股骨及前臂骨密度;采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法,对179例北京地区汉族妇女ER基因XbaI多态性进行分析。北京地区汉族妇女ER基因XX、Xx和xx基因型频率分布为0.302、0.464和0.234,绝经前与绝经后妇女XbaI型基因频率分布有明显差异,绝经后妇女腰椎骨密度(0.836±0.18)g cm2明显低于绝经前妇女(1.038±0.14);绝经后妇女骨质疏松症的发病率为54%。ER基因XbaI基因型频率分布有明显的种族差异并受绝经影响,ER基因XbaI基因型与骨密度无明显相关性。与体重和BMI有明显相关性。The work is to study the relationship between XbaI polymorphisms of the estrogen receptor(ER) gene and bone mineral density in Beijing Han women.Bone mineral density(BMD) was measured at lumbar spine,proximal femoral and arm by dual energy X-ray absorptionetry(DEXA) and ER gene was determined by polymerase Chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 179 Beijing Han women.The frequency of the ER genotype of XX?Xx and xx was 0.302,0.464 and 0.234 in Beijing Han women.There was a signficant difference between premenopausal and postmenopausal women in the frequency of the XbaI genotype.The BMD of lumbar spine in postmenopausal women(0.836±0.18g/cm2)was significally lower than that in premenopausal women (1.038±0.14g/cm2)(P<0.01) and the incidence of osteoporosis in postmenopausal women was 54.3%.The frequency of XbaI genotype of ER gene in Han women.There was apparently different from that in other races in and menopause effected on the frequency of XbaI genotype.The XbaI genotype of ER gene was nonassociated with BMD.and significantly associated with BMI.

关 键 词：雌激素受体 XbaI基因型 骨密度 体重指数 

分 类 号：Q987[生物学—遗传学]