肝素结合表皮生长因子样生长因子在银屑病早期皮损中的意义  

Significance of Heparin Binding Epidermal Growth Factor-like Growth Factor in Early Psoriatic Lesions

作　　者：郑焱[1] 彭振辉[1] 谭升顺[1] 郗彦萍[1] 王一理[2] 来宝长[2] 

机构地区：[1]西安交通大学第二医院皮肤科,710004 [2]西安交通大学第二医院免疫病理教研室,710004

出　　处：《中华皮肤科杂志》2003年第3期136-138,共3页Chinese Journal of Dermatology

基　　金：国家自然科学基金资助项目(30070699)

摘　　要：目的探讨肝素结合表皮生长因子样生长因子(HB-EGF)在银屑病发病早期中的作用机制。方法用原位杂交和免疫组化的方法检测正常组织、进行期银屑病皮损及其未受累皮肤中HB-EGFmRNA和蛋白表达。结果在正常人皮肤组织中,HB-EGFmRNA和蛋白位于基底层(100%),基底上层仅有少量表达(16.67%);在未受累表皮和银屑病皮损的周围部分中,HB-EGF的表达不仅位于基底层,且以灶状高表达于基底上层(分别为88.00%、80.00%);在银屑病皮损的中央部分,基底上层无HB-EGF表达,基底层几乎不表达(4.00%)。结论HB-EGF可能在银屑病发病的早期阶段起重要作用。Objective To investigate the role of heparin binding epidermal growth factor-like growth factor(HB-EGF)in active psoriasis vulgaris.Methods HB-EGF mRNA and protein were detected by hy-bridization in situ and immunohistochemistry in normal skin tissues,lesional and non-lesional psoriatic skin of progressive stage.Results In normal skin tissues,the stain of HB-EGF mRNA and protein was located in the basal layer of epidermis(100.00%)and there was only a little expression in the suprabasal layers(16.67%).Focal overexpression was found in the suprabasal layers of non-lesional and peri-lesional psoriat-ic skin(88.00%,80.00%respectively);however,there was no HB-EGF mRNA protein expression in the superabasal layers of the central part of psoriatic lesions(0),and nearly no expression in the basal layer(4.00%).Conclusion HB-EGF may play an important role in the pathogenesis of early psoriasis.

关 键 词：银屑病 早期皮损 肝素 表皮生长因子样生长因子 蛋白表达 作用机制 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]