解偶联蛋白与肥胖及2型糖尿病发病的关系  

Role of Uncoupling Proteins in the Pathogenesis of Obesity and Type II Diabetes

作　　者：万春玲[1] 张铁梅[2] 王沥[1] 杨泽[2] 金锋[1] 

机构地区：[1]中国科学院遗传与发育生物学研究所,北京100101 [2]卫生部北京医院卫生部北京老年医学研究所老年医学重点实验室,北京100730

出　　处：《遗传》2003年第2期211-220,共10页Hereditas（Beijing)

基　　金：中国科学院创新工程基金;973研究项目(G2000057007);863计划项目(2002AA223031)资助

摘　　要：解偶联蛋白(UCPs)是线粒体内膜上的一种转运蛋白,它能够降低线粒体内膜上的质子梯度,使底物氧化和ADP磷酸化解偶联,减少ATP的产生。基于其功能,解偶联蛋白基因被视为肥胖病及2型糖尿病的重要候选基因。UCP同系物过表达的遗传工程小鼠表现出对饮食导致的肥胖具有耐受性,同时UCP2基因3'非翻译区的45bp插入/缺失以及UCP3基因C-55T多态与肥胖表型的相关性等研究结论支持这一假说。本文对UCP基因与多基因控制的肥胖病及2型糖尿病发病的相关研究进行综述和讨论。Uncoupling proteins (UCPs) are mitochondria carrier proteins,which are able to dissipate the proton gradient of the inner mitochondria membrane.The uncoupling procedure reduces the amount of ATP generated through an oxidation of fuels.Therefore,UCPs are suggested as candidate genes for human obesity or type II diabetes mellitus.Experimental evidences, that genetically engineered mice over expressing different UCP homologues were resistant to diet-induced obesity and 45bp insertion polymorphism in the UCP2 3'untranslated region and C-55T in UCP3 promoter region were associated with obesity related phenotype,supported the hypothesis.The roles of UCP genes in polygenic obesity and type II diabetes are evaluated and discussed in this paper.

关 键 词：肥胖 2型糖尿病 能量代谢 基因多态 解偶联蛋白 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]