男性肥胖患者胰岛素抵抗与瘦素抵抗的相关性分析  

The relationship between leptin resistance and insulin resistance in men with obesity

作　　者：范爱红[1] 陈燕[1] 徐卓华[1] 叶山东[1] 

机构地区：[1]安徽省立医院内分泌科,合肥230001

出　　处：《临床中老年保健》2003年第1期21-22,共2页

摘　　要：目的　探讨男性肥胖者瘦素抵抗与胰岛素瘦素抵抗的相关性。方法　 35例肥胖男性和 30例正常对照组均进行葡萄糖耐量试验 ,空腹血清瘦素及胰岛素采用放射免疫法。空腹血糖及餐后 2h血糖采用氧化酶法 ,同时测每例受试者身高、体重 ,计算体重指数 (BMI =体重 /身高2 )。结果　肥胖组空腹血清瘦素(14 92± 10 38pmol/L)与对照组 (6 6 5± 2 73pmol/L)相比差异有显著意义 (P <0 0 1) ,肥胖组空腹血清胰岛素水平 (11 2 6± 3 90mIU/L)与健康对照组 (6 73± 2 4 8mIU/L)相比差异也有显著意义 (P <0 0 1) ,两组空腹血糖差异无显著意义 ;肥胖组内空腹瘦素与胰岛素相关分析显示两者呈显著正相关 (r =0 5 75 ,P <0 0 1)。结论　肥胖患者存在瘦素抵抗及胰岛素抵抗 。Objective To probe into the relationship between leptin resistance and insulin resistance in men with obesity.Methods Fasting leptin and insulin levels were measured with RIA,and oral glucose tolerance test was carried out in every case to measure serum glucose concentration with glucose oxidase in 35 men with obesity and 30 control subjects,meanwhile,height,body weight were measured to calculate body mass index(BMI).Results Fasting serum leptin and insulin were higher in obese men than those in normal subjects(both P<0.01),and fasting blood glucose was no various change.Two variable correlation analysis showed that leptin level were positively correlated with insulin level in obese group(r=0.575,P<0.01).Conclusion LR(leptin resistance) and IR(insulin resistance) exist in obese men,and LR is positively correlated with IR.

关 键 词：男性 相关性分析 肥胖 瘦素抵抗 胰岛素抵抗 

分 类 号：R589.2[医药卫生—内分泌]