突然扩张流槽中血管内皮细胞表面粘附蛋白表达的研究  

EXPRESSION OF SURFACE ADHESION PROTEINS ON CULTURED VASCULAR ENDOTHELIAL CELLS IN SUDDEN-EXPENSION FLOW CHAMBER

作　　者：胡江[1] 胡嘉[1] 李涛[1] 高宇欣[1] 陶祖莱[1] 

机构地区：[1]中国科学院力学研究所国家微重力实验室,北京100080

出　　处：《生物物理学报》2003年第1期97-100,共4页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(19732003)

摘　　要：动脉粥样硬化的非随机分布与当地的血流动力环境有关,为了研究复杂的流体动力学条件对血管内皮细胞生理功能的影响,构建了平行板式平直流槽和突然扩张流槽,通过数值模拟分析了流型的特征,并探讨流型改变对人脐静脉血管内皮细胞表面粘附蛋白表达的影响,发现突然扩张流槽中流动的空间变化使得总体细胞表面粘附蛋白JCAM-1的表达显著高于平直流槽中的均匀定常剪切作用,表明局部流动空间变化的性质可以影响血管内皮细胞的功能。The non-random distribution of atherosclerosis was related to local hemodynamic environment. Parallel plate rectangle and sudden-expansion flow chamber were constructed in our studies and the flow characteristics in these chambers were analyzed using finite-volume models. The effect of flow pattern on expression of surface adhesion proteins on cultured HUVEC was studied. It was shown that at the same entrance Re number or the mean shear stress condition, the expression of ICAM-1 was higher in sudden-expansion flow chamber than in rectangle flow chamber. There was no effect on E-Selectin expression. In conclusion, the spatial characteristic of fluid flow would influence local function of vascular endothelial cells.

关 键 词：流型 内皮细胞 表面粘附蛋白 

分 类 号：Q6[生物学—生物物理学]