珠子肝泰治疗慢性乙型肝炎的免疫组织化学研究  

Study on Immune Histochemistry of Chronic Hepatitis B Patients Treated with Zhuzi Gantai (ZGT)

作　　者：陈义 蔡艳梅[2] 吴斌 马涛 

机构地区：[1]兰州肝病研究所临床研究室,甘肃兰州730046 [2]兰州市第二人民医院

出　　处：《中西医结合肝病杂志》2003年第1期6-7,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:观察珠子肝泰对慢性乙型肝炎患者肝组织内HBsAg和HBcAg的影响。方法:对21例慢性乙型肝炎应用珠子肝泰进行治疗,3次/d,每次4粒(0.8g),疗程6个月。在治疗开始前和疗程结束后采集血清和肝组织标本,进行血清学、病理学和免疫组织化学检查。结果:治疗后,血清内HBeAg和HBV DNA的转阴率分别为45.0％和47.4％,81％的患者肝组织损伤改善或修复,45.4％的患者肝纤维化程度减轻,肝内HBsAg和HBcAg的转阴率分别为19.0％和23.8％。结论:珠子肝泰在抑制慢性乙型肝炎患者血清HBV复制标志和改善肝组织病理损伤程度的同时,对肝细胞内乙肝病毒感染因子也有一定抑制作用。Objective: To observe the effects of ZGT on HBsAg and HBcAg in patients with chronic hepatitis B. Methods: 21 patients with chronic hepatitis B were treated with ZGT three times daily for 6 months. The serum levels, pathology and immune histochemistry of all patients were detected before and after treatment. Results: At the end of the treatment, the seronegation of HBeAg and HBV DNA were 45.0 % and 47.4 % , negative rate of HBsAg and HBcAg in liver were 19.0% and 23.8% , the liver function of 81% patients were improved, and the degrees of the liver fibrosis of the 45% patients were lessened. Conclusion: The results suggested that ZGT could inhibit the replications of HBV, improve the liver function and affect the infected factor of Hepatitis B virus.

关 键 词：乙型肝炎 中医学 珠子肝泰/治疗应用 免疫组织化学 

分 类 号：R259[医药卫生—中西医结合]