黄芪注射液对糖尿病肾病患者血、尿转化生长因子β_1的影响及意义  

THE INFLUENCE OF INJECTION ASTRAGULUS MEMBRANACEUS ON SERUM AND URINE TGF β_1 IN DIABETIC NEPHROPATHY PATIENTS AND CLINICAL SIGNIFICANCE

作　　者：陶松桔[1] 尹支农[2] 谭辉[1] 

机构地区：[1]湖南省郴州市第一人民医院呼吸内分泌科,423000 [2]湖南省郴州市第一人民医院药剂科

出　　处：《中国现代医学杂志》2003年第6期49-51,共3页China Journal of Modern Medicine

摘　　要：目的 :观察黄芪注射液对糖尿病肾病 (DN)患者血、尿转化生长因子 β1(TGFβ1)的影响 ,探讨黄芪注射液治疗糖尿病肾病 (DN)的机制。方法 :分别测定黄芪注射液治疗组 ( 2 8例 ) ,对照组 ( 2 6例 )治疗前后血、尿TGFβ1尿白蛋白排泄率 (UAER)、血糖、糖化血红蛋白 (HbA1c)。结果 :黄芪注射液能明显降低DN患者血、尿TGFβ1水平 ,减少DN患者UAER ,具有降低HbA1c的作用。结论 :黄芪注射液对DN患者肾脏有保护作用 ,可能与其抑制DN患者TGFβ1有关。Objective:To observe the influence of injection dastragaulus membranaceus (IAM) on serum and urine TGF β 1 in diabetic nephropathy patients and to investigate the therapeutic mechanism of IAM on diabetic nephropathy. Methods:Serum and urine TGF β 1,UAER, blood glucose,HbA1c were determined in the treatment group and control group respectively.Results:IAM can significantly lower serum and urine TGF β 1 in diabetic nephropathy patients, concurrently decrease UAER,HbA1c of diabetic nephropathy patients. Conclusion:IAM has protection against diabetic nephropathy. It's protective role is connected with its inhibiting TGF β 1 in diabetic nephropathy patients.

关 键 词：黄芪注射液 糖尿病肾病 转化生长因子Β1 影响 临床意义 血液尿液 

分 类 号：R259.872[医药卫生—中西医结合]