γ-干扰素治疗36例慢性乙型肝炎的临床观察  

The Effect of Interferon-γon Chronic Hepatitis B in36Patients

作　　者：张平[1] 李伟[1] 张玉荣[1] 陈静[1] 

机构地区：[1]天津市传染病医院,300192

出　　处：《天津医药》2003年第4期219-221,共3页Tianjin Medical Journal

摘　　要：目的 :探讨慢性乙型肝炎有效的治疗方法。方法 :根据乙肝病毒的感染来源了解免疫耐受情况 ,对36例有乙肝家族史的慢性乙肝用γ_干扰素治疗3个月 ,并与未经γ_干扰素治疗的38例作同期对照。结果 :观察组病人血清透明质酸 (HA)、层粘连蛋白 (LN)、四型胶原 (IV_C)、前三胶元 (PcIII)的降低明显有效 ,而且在HBeAg和HBV_DNA阴转及水平减低、A/G比值改善率、减轻门静脉扩张程度、治疗后病情稳定方面均与对照组存在显著性差异(P<0.05)。结论 :免疫耐受程度高的慢性乙型肝炎首先应考虑抗纤维化治疗 ,γ -干扰素是最有前途的抗纤维化药物之一。Objective:To explore the effective method for the treatment of chronic hepatitis B.Methods:Thirty_six chronic hepatitis B patients with a family history of chronic hepatitis B were treated with interferon_γ(IFN_γ)for3months,and38chronic hepatitis B patients without the treatment of IFN_γas control.Results:HA,LN,IV_C,and PcIII significantly decreased in IFN_γtreatment group.There was a significant difference in HbeAg and HBV_DNA negative change,levels decrease,improving rate of A/G,reducing diameter of portal,and the recurrent rate of chronic hepatitis B between two groups(P<0.05).Conclusion:Interferon_γis an effective drug in treating chronic hepatitis B.

关 键 词：Γ-干扰素 治疗 慢性乙型肝炎 临床观察 

分 类 号：R512.62[医药卫生—内科学]