猴头多糖抗肿瘤及对免疫功能的影响  

Hericium erinaceus polysaccharide and its antineoplastic activity and influence on immunity on mice

作　　者：聂继盛[1] 祝寿芬[1] 

机构地区：[1]山西医科大学,030001

出　　处：《山西医药杂志》2003年第2期107-109,共3页Shanxi Medical Journal

基　　金：山西省教委开发项目 ( 1996)

摘　　要：目的　研究猴头多糖 ( HEPS)对小鼠 S1 80 肉瘤及免疫功能的影响。方法　 H EPS按 10 0、2 0 0、40 0m g/ kg体重连续灌胃 15 d,测定荷瘤小鼠瘤重 ,通过检测小鼠抗体生成细胞、迟发性变态反应、NK细胞活性 ,荷瘤小鼠免疫器官分别检测 HEPS对体液免疫、细胞免疫、非特异免疫及异常免疫的调节作用。结果　 HEPS可显著抑制 S1 80 肉瘤的生长 ,提高荷瘤小鼠胸腺和脾重 ,增强正常小鼠抗体形成细胞溶解绵羊红细胞能力、迟发型变态反应能力、NK细胞活性。结论　Objective To research the hericium erinaceus polysaccharide (HEPS) isolated from a kind of Heicium erinaceus gathered in Shanxi province,and its antineoplastic activity and immunological influence.Method HEPS was administered orally at the dose of 100,200 and 400 mg/kg for consecutive 15 days.Inhibition rate of tumor growth,indexes of spleen and thymus in tumor model mice were checked;meanwhile,dissolving power of antibody-forming cell to SRBC,delayed allergy,and NK activity were respectively determined in normal mice.Results HEPS can inhibit the growth of sarcoma 180 at different doses,raise the indexes of spleen and thymus significantly,also improving the dissolving power to SRBC of antibody forming cell,delayed allergy and NK activity in normal mice.Conclusion HEPS has antineoplastic activity and immunoregulation.

关 键 词：猴头多糖 抗肿瘤 免疫功能 实验研究 

分 类 号：R285[医药卫生—中药学]