古拉定对急性酒精中毒的治疗作用  

ROLE OF GLUTHION IN THE TREATMENT OF PATIENTS WITH ACUTE ALCOHOL INTOXICATION

作　　者：郭长吉[1] 林三仁[1] 陈菲[1] 王燕[1] 

机构地区：[1]北京大学第三医院,北京100083

出　　处：《医师进修杂志》2003年第4期20-21,共2页Journal of Postgraduates of Medicine

摘　　要：目的　观察古拉定对急性酒精中毒 (AAI)治疗作用。方法　对 2 0 0 1年 7～ 1 0月来诊且符合AAI诊断标准的40例病人随机分为两组 :古拉定组和纳络酮组。主要观察指标包括 :饮酒量、饮酒至开始治疗时间、开始治疗至神志及肢体运动恢复正常时间、用药前及用药后 2h血液酒精浓度。结果　自治疗至神志恢复正常时间 :古拉定组(1 .4± 0 .7)h ,纳络酮组 (5 .2± 5 .5)h ,P <0 .0 1 ;至四肢运动恢复正常时间 :古拉定组 (1 .7± 0 .9)h ,纳络酮组 (6 .1± 5 .6)h ,P <0 .0 0 5 ;治疗 2h后血液酒精浓度下降幅度 :古拉定组 (1 0 .5± 7.3)mmol/L ,纳络酮组 (5 .7± 4 .6)mmol/L ,P <0 .0 5。Objective\ To investigate the therapeutic effects of gluthion on acute alcohol intoxication.Methods\ The patients diagnosed as having acute alcohol intoxications were randomly divided into two groups:gluthion group and naloxone group.The volume of drinking,the interval from drinking to treatment and from the beginning of treatment to full consciousness and normalization of extremities movement,the blood concentration of ethanol before and after 2 hours of treatment were compared between the two groups.Results\ It was (1.4±0.7) hours in gluthion group and (5.2±5.5) hours in naloxone group to get full consciousness from the beginning of treatment (P<0.01).The interval was (1.7± 0.9 ) hours in gluthion group and (6.1±5.6) hours in naloxone group from the beginning of treatment to the normalization of extremities movement (P<0.005).The blood concentration of ethanol was reduced by (10.5±7.3) mmol/L in gluthion group and (5.7±4.6) mmol/L in naloxone group after 2 hours of treatment (P<0.05).Conclusion\ Gluthion is very effective in the treatment of acute alcohol intoxication.

关 键 词：古拉定 急性酒精中毒 治疗 谷胱甘肽 

分 类 号：R595.6[医药卫生—内科学]